Table 1.
Summary of antibodies and virus strains used in the study.
A. mAbs used | Target on Env | |||||
---|---|---|---|---|---|---|
4E10 | MPER* | |||||
2F5 | MPER* | |||||
2G12 | V3 glycans† | |||||
b12 | CD4bs† | |||||
PG9 | V1/V2 loop† | |||||
PG16 | V1/V2 loop† | |||||
B. env strains used for Pseudovirus | Clade | Subject identifier | Accession Number | Gender | Mode of Transmission | Fiebig Stage b |
SF162 | B | N.A. | EU123924 | Male | N/A | VI |
AC10.0.29 | B | AC10.0 | AY835446 | Male | MSMa | III |
REJO4541.67 | B | REJO4541 | AY835449 | Male | HSX | II |
RHPA4259.7 | B | RHPA4256 | AY835447 | Female | HSX | ≤ V |
THRO4156.18 | B | THRO4156 | AY835448 | Male | MSM | II |
C. IMC of T/F strains | ||||||
CH040.c | B | 700010040 | JN944939 | Male | MSM | T/F IMCc |
CH058.c | B | 700010058 | JN944940 | Male | MSM | T/F IMCc |
CH077.t | B | 700010077 | JN944941 | Male | MSM | T/F IMCc |
REJO.c | B | REJO4541 | JN944943 | Male | HSX | T/F IMCc |
RHPA.c | B | RHPA4256 | JN944944 | Female | HSX | T/F IMCc |
THRO.c | B | THRO4156 | JN944947 | Male | MSM | T/F IMCc |
A. Monoclonal antibodies used and respective target epitope on Env; * on gp41 and † on gp120
B-C. Virus used: Pseudovirus (B) and Transmitted/Founders (T/F) IMCs (C).
aMSM, men who have sex with men; HSX, heterosexual.
bThe stage of HIV-1 infection, as defined by Fiebig et al. [15], at which samples were obtained.
cT/F IMCs represent the genomes of the strains that initiated clinical infection in the respective subjects. For detailed description, see C. Ochsenbauer et al., [2].