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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Biomaterials. 2014 Dec 9;41:166–175. doi: 10.1016/j.biomaterials.2014.11.016

Fig. 5.

Fig. 5

PPS microspheres provide sustained, on demand local curcumin release and reduce tissue ROS levels in the ischemic limb in vivo. A) Curcumin-PPS microspheres release curcumin more rapidly in the ischemic limb in comparison to the control limb. B) ROS levels in the gastrocnemius muscle are increased at day 1 post-surgery (level of ROS is 2.3-fold greater in ischemic versus control gastrocnemius). C) Blank PPS microspheres and curcumin-loaded PPS microspheres significantly reduce ROS in gastrocnemius muscles extracted from ischemic limbs. Data presented as mean ± SEM. Saline group n=8, blank PPS group n=11, curcumin-PPS group n=10. *p<0.05 relative to saline treatment.