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. 2014 Oct 15;3:14049. doi: 10.1038/mtm.2014.49

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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AADC expression in the mid-brain of (a) pilot and (b) toxicology study animals. AADC staining of mid-brain revealed good correlation between infusate (gadolinium) signal in MRI and AAV2-hAADC expression (left and middle columns). AADC signal (brown) in SNpc and VTA that colocalized with endogenous tyrosine hydroxylase signal (blue, middle column). Although transgenic AADC in these nuclei was indistinguishable from endogenous AADC, AAV2-hAADC gene product was easily visible in SNpr when compared to naïve animal images. Higher magnification images show transgenic AADC staining in cells and fibers (right column). Scale bars: Left and middle columns: 1 cm; right column: 200 μm.