Table 2. Transgenic AADC-positive fibers in striatum (caudate nucleus and putamen) and nucleus accumbens.
| NHP ID (survival) | Caudate nucleus | Putamen | Nucleus accumbensa |
|---|---|---|---|
| Control group | |||
| V002326 (1 month) | − | − | − |
| V002215 (1 month) | − | − | − |
| V002397 (3 months) | − | − | − |
| V002458 (9 months) | − | − | − |
| AAV2-hAADC low dose group | |||
| V002243 (1 month) | +++ | +++ | − |
| V002274 (1 month) | ++/+++ | ++/+++ | − |
| V002254 (3 months) | + | + | − |
| V002294 (3 months) | ++/+++ | ++/+++ | + |
| V002100 (9 months) | +++ | ++ | ++ |
| V002276 (9 months) | +++ | ++ | |
| AAV2-hAADC high dose group | |||
| V002332 (1 month) | +++ | ++ | − |
| V002370 (1 month) | ++/+++ | ++/+++ | − |
| V002224 (3 months) | +++ | ++/+++ | + |
| V002304 (3 months) | ++/+++ | ++ | − |
| V002325 (9 months) | ++ | +/++ | − |
| V002450 (9 months) | +++ | +++ | + |
AADC-ir fiber staining rating: −, absent (endogenous AADC staining); +, low intensity/sparse fiber staining; ++, intermediate intensity/many positive fibers; +++, high intensity/dense fiber staining.
a
AADC-positive fibers were found only in nucleus accumbens core.