Table 3. Off-target expression of transgenic hAADC protein.
Brain structure | AAV2-hAADC low dose | AAV2-hAADC high dose |
---|---|---|
Globus pallidus | F | F |
Thalamus | F/Ca | F/Ca |
Medial forebrain bundle | – | F |
Subthalamic nucleus | F/Ca | F/Ca |
Substantia nigra pars reticulata | F | F |
Red nucleus | F/C | F/C |
Spinal cord | – | F |
Other | F | F |
Corona radiata/IC area dorsal to SN | Corona radiata/IC area dorsal to SN |
C, cells; F, fibers; IC, internal capsule.
Surrounding cannula tract.