Table 2.
GPA test parameters
| ABCA1 |
Low HDL-C |
||||
|---|---|---|---|---|---|
| Homozygous | Heterozygous | Control subjects | Case subjects | Control subjects | |
| n = 3 | n = 8 | n = 8 | n = 9 | n = 9 | |
| AIRarg (μU/mL) | 62 ± 32a | 33 ± 8 | 28 ± 7 | 58 ± 10* | 27 ± 6 |
| AIRpot (µU/mL) | 350 ± 228a | 195 ± 33* | 122 ± 20 | 278 ± 45† | 134 ± 14 |
| AIRmax (µU/mL) | 426 ± 153* | 219 ± 30* | 173 ± 34 | 304 ± 66† | 143 ± 20 |
| ACRarg (ng/mL) | 3.47 ± 0.86* | 2.03 ± 0.36* | 1.43 ± 0.26 | 3.07 ± 0.29* | 1.64 ± 0.25 |
| ACRpot (ng/mL) | 14.17 ± 6.24a | 8.31 ± 1.70* | 6.30 ± 0.97 | 9.70 ± 1.06† | 5.24 ± 0.52 |
| ACRmax (ng/mL) | 14.08 ± 6.01* | 8.39 ± 1.16* | 5.77 ± 0.55 | 10.45 ± 1.66* | 5.60 ± 0.65 |
| M (mg/kg/min) | 9.8 ± 0.1 | 9.6 ± 0.5 | 9.4 ± 0.7 | 8.7 ± 0.4 | 10.3 ± 1.0 |
| I (µU/mL) | 52 ± 25 | 45 ± 11 | 28 ± 4 | 50 ± 10 | 34 ± 6 |
| M/I (mg/kg per min/µU/mL) | 0.30 ± 0.12 | 0.29 ± 0.05 | 0.36 ± 0.03 | 0.22 ± 0.03† | 0.37 ± 0.06 |
| DI (mg/kg/min) | 11.0 ± 1.8 | 9.0 ± 2.6 | 9.7 ± 2.3 | 11.0 ± 1.5 | 10.4 ± 3.6 |
Data are means ± SE.
ACRarg, acute C-peptide response to arginine under fasting conditions; ACRmax, acute C-peptide response to arginine under ∼340 mg/dL glucose clamp conditions; ACRpot, acute C-peptide response to arginine under ∼230 mg/dL glucose clamp conditions.
aP ≤ 0.1 case subjects vs. control subjects.
*P < 0.05 case subjects vs. control subjects.
†P < 0.01 case subjects vs. control subjects.