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. 2014 Jul 22;64(1):12–22. doi: 10.2337/db14-0192

Figure 1.

Figure 1

High-fat diet (HFD) feeding promotes SIRT1/DBC1 interaction and decreases SIRT1 activity in fat tissue. A: SIRT1 levels in inguinal fat tissue from 6-month-old mice fed the normal chow diet (ND) or the HFD for 20 weeks (n = 5 mice per group). *P < 0.05. B: Representative Western blot (left) of coimmunoprecipitation between SIRT1 and DBC1 in fat tissue from mice fed the ND or HFD, with each lane corresponding to a different mouse, and quantitation (right) of SIRT1/DBC1 interaction by densitometry (n = 4 mice per group). *P < 0.05. C: SIRT1 activity from immunoprecipitates of inguinal fat tissue in mice in fed the ND or HFD (n = 5 mice per group). *P < 0.05.