Table 1.

Insulin analogues and recombinant variations, structure, and related immunogenic reactions.

Immunogenic molecules	Reaction type	References
Regular human insulin
Insulin	I	[8, 10–15]
	III	[15]
Crystalline insulin
Insulin	I	[8, 16, 17]
Porcine insulin
Insulin	I	[8, 16]
Bovine insulin
Insulin	I	[8, 16]
Neutral Protamine Hagedorn (NPH) insulin
Insulin	I	[8, 10, 11, 17]
	IV	[18]
Protamine	I	[8, 10, 19]
Lispro insulin (Humalog)
Insulin	I	[8, 12, 15]
	III	[15]
Aspart insulin (NovoLog)
Insulin	I	[8, 16, 20]
Glargine insulin (Lantus)
Insulin	I	[11, 12, 21]
	III	[14]
Detemir insulin (Levemir)
Insulin	I	[12, 22]
	III	[14, 23]
	IV	[22]
Metacresol	I	[24]