Table 1.
Baseline characteristics, treatment-related variables, and long-term outcomes in all patients with clinical stage IIIA NSCLC who received combination therapy. This table shows an unmatched comparison. The CR group refers to patients who received chemotherapy and radiation in any sequence. The CRS group refers to patients who underwent chemotherapy, radiation therapy, and surgery in any sequence.
| Chemotherapy and Radiation (CR) (n=51979) |
Chemotherapy, Radiation and Surgery (CRS) (n=9360) |
P value |
|
|---|---|---|---|
| Age (years) | 66.3 ± 10.0 | 61.3 ± 9.9 | <.001 |
| Male Gender | 30133 (58.0%) | 5034 (53.8%) | <.001 |
| Caucasian | 44935 (87.1%) | 8281 (89.2%) | <.001 |
| Urban Location | 32182 (65.2%) | 6162 (70.2%) | <.001 |
| Income >$35000/year | 30876 (62.4%) | 6184 (69.9%) | <.001 |
| Charlson/Deyo Score (available n=35717, CR, n=6713, CRS) | 0 23774 (66.6%) 1 8669 (24.3%) 2 3274 (9.2%) |
0 4497 (67.0%) 1 1765 (26.3%) 2 451 (6.7%) |
<.001 |
| Distance traveled for treatment (miles) | 37.5 ± 387.0 | 92.2 ± 775.4 | <.001 |
| Tumor Size (mm) | 48.1 ± 39.5 | 43.0 ± 33.5 | <.001 |
| Facility Reporting Case | Community Cancer Program: 9464 (18.2%) Comprehensive Community Cancer Program: 28183 (54.2%) Academic/Research Program: 13537 (26.0%) Other: 795 (1.5%) |
Community Cancer Program: 1211 (12.9%) Comprehensive Community Cancer Program: 4471 (47.8%) Academic/Research Program: 3501 (37.4%) Other: 177 (1.9%) |
<.001 |
| Chemotherapy type | Single agent: 4193 (9.1%) Multiagent: 42082 (90.9%) |
Single agent: 413 (5.0%) Multiagent: 7849 (95.0%) |
|
| Chemotherapy-Surgery sequence (available n=4535) | Before surgery: 2185 (48.2%) After surgery: 1843 (40.6%) Before and after surgery: 507 (11.2%) |
||
| Cumulative Radiation Dose (cGy) | 5914.1 ± 3831.8 (26.6% Missing) | 5295.0 ± 2901.8 (27.6% Missing) | <.001 |
| Cumulative radiation dose (cGy) (available n=38166) | ≤4000: 5678 (14.9%) 4001–5000: 4032 (10.6%) 5001–6000: 7643 (20.0%) >6000: 20813 (54.5%) |
||
| Cumulative radiation dose (cGy) (n=6774) | ≤3500: 344 (5.1%) 3501–4500: 1971 (29.1%) >4500: 4459 (65.8%) |
||
| Radiation-Surgery sequence (available n=9044) | Before surgery: 4749 (52.5%) After surgery: 4140 (45.8%) Before and after surgery: 155 (1.7%) |
||
| Type of operation | Lobectomy: 6284 (67.1%) Pneumonectomy: 1517 (16.2%) Other: 1559 (16.7%) |
||
| Median Survival (months) | 15.7 ± 0.1 | 32.4 ± 0.6 | <.001 |