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The feto-maternal interface. The extravillous trophoblast cells invades the maternal decidua and the spiral arteries, possibly remodeling these in order to increase blood flow to the fetus as pregnancy progresses. HLA-G and HLA-E protect invading trophoblast cells from lysis by NK cells throughout pregnancy, while HLA-F is expressed on the surface of extravillous trophoblast cells at later stages.
