Table 4.
Prevalence of anti-PLA2R autoantibodies in patients with primary membranous nephropathy
| Author (Year) | Patients (n) | anti-PLA2R (%) | Assay |
|---|---|---|---|
| Beck (2009) 8 | 37 | 70% | WB |
| Hofstra (2011) 101 | 18 | 78% | WB |
| Beck (2011) 81 | 35 | 71% | WB |
| Debiec (2011) 77 | 42 | 57% | IFA |
| Hoxha (2011) 75 | |||
| •Entire cohort | 100 | 52% | IFA |
| •Active disease | 35 | 66% | |
| Qin (2011) 76 | |||
| •Active disease | 60 | 82%* | WB |
| •Remission | 21 | 19% | |
| Bruschi (2011) 89 | 24 | 58% | WB |
| Gunnarsson (2012) 102 | 3 | 100% | IFA |
| Hoxha (2012) 80 | 88 | 68% | IFA |
| Hofstra (2012) 79 | 117 | 74% 72% |
IFA ELISA |
| Murtas (2012) 90 | 111 | 60% | WB, IFA |
| Svobodova (2012) 103 | |||
| •Active disease | 31 | 65% | IFA |
| •Remission | 37 | 22% | |
| Kanigicherla (2013) 104 | |||
| •Active disease | 40 | 75% | ELISA |
| •Partial remission | 27 | 37% | |
| •Complete remission | 23 | 10% | |
| Coenen (2013) 105 | 82 | 52% | IFA |
| Behnert (2013) 106 | 160 | 53% | ALBIA |
| Oh (2013) 107 | |||
| •At time of biopsy | 100 | 69% | WB |
| •Proteinuria > 3.5 g/g | 75 | 80% | |
| •Remission | 19 | 16% | |
WB=Western blot; IFA=Indirect immunofluorescence assay; ELISA=Enzyme-linked immunosorbent assay; ALBIA=addressable laser bead immunoassay
*
when tested at 1:10, 98% (59/60) samples were positive by WB