. Author manuscript; available in PMC: 2014 Dec 23.

Published in final edited form as: J Autoimmun. 2011 Mar 16;36(0):263–277. doi: 10.1016/j.jaut.2011.02.005

Table I.

Numbers of CD4⁺ and CD8⁺ T cells in NOD and IL-18KO NOD lymphoid organs.

		NOD	IL-18 KO NOD	NOD	IL-18KO NOD
		4–6 wk	4–6 wk	9–10 wk	9–10 wk
Total cells (× 10⁶)	Spleen	49.9 ± 19.1	68.4 ± 24.5 ^*	62.8 ± 6.7	75.7 ± 6.9 ^*
		n=20	n=20	n=9	n=9
	panLN	2.2 ± 1.0	1.8 ± 0.9	2.7 ± 0.6	1.8 ± 0.8 ^*
		n=21	n=21	n=8	n=8
No. CD4+ (× 10⁶)	Spleen	14.0 ± 3.6	25.4 ± 10.3 ^*	19.8 ± 3.1	25.9 ± 4.6 ^*
		n=20	n=20	n=9	n=9
	panLN	1.0 ± 0.5	1.0 ± 0.5	1.3 ± 0.2	0.9 ± 0.1 ^*
		n=21	n=21	n=8	n=8
No. CD8+ (× 10⁶)	Spleen	6.2 ± 1.6	12.6 ± 6.1 ^*	7.6 ± 2.1	13.1 ± 3.2 ^*
		n=20	n=20	n=9	n=9
	panLN	0.51 ± 1.0	0.36 ± 0.2 ^*	0.66 ± 0.1	0.39 ± 0.1 ^*
		n=21	n=21	n=8	n=8

Absolute numbers of each cell type were calculated by multiplying the cellular percentages obtained by flow cytometry by the total cell counts for each organ from individual mice. Data are presented as the mean ± SD where n equals the number of mice examined. For each individual mouse, a minimum of 200, 000 gated lymphocytes, 30, 000 CD4⁺ cells and 10, 000 CD8⁺ cells were enumerated by flow cytometry.

^(*)

p<0.05 for comparisons of NOD and IL-18KO NOD cells within a particular age category.