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. 2014 Sep 3;24(2):383–396. doi: 10.1093/hmg/ddu451

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Schwann cell conditional ablation of Fig4 in the Fig4^Floxed/plt, P0-Cre mouse resulted in a milder phenotype. (A and B) Semithin section analysis of sciatic nerves of Fig4^Floxed/plt, P0-Cre when compared with Fig4^{Floxed/Floxed}, P0-Cre at 4 months. The percentage of fibres carrying vesicles/myelin debris in the Schwann cell cytoplasm is higher in Fig4^{Floxed/Floxed}, P0-Cre mice. Myelinated fibres from Fig4^Floxed/plt, P0-Cre sciatic nerves at 8 months showing demyelinating features such as redundant myelin (D), myelin degeneration (E), and onion bulbs (F–F′′). Fig4^Floxed/plt, P0-Cre sciatic nerves analysed at P30 (G and H) have increased g-ratio values indicating developmental hypomyelination. Bar in (A) is 10 µm for (A and B); bar in (F′′) is 1.7 µm for (C); 1 µm for (D); 1.7 µm for (E); 3 µm for (F); 2.4 µm in (F′) and 5 µm for (F′′).