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. 2014 Sep 3;24(2):383–396. doi: 10.1093/hmg/ddu451

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Cholesterol supplementation does not rescue Fig4^Floxed/plt, P0-Cre hypomyelination in vitro. (A and B) Cholesterol supplementation accelerates myelination of control explants after 7 days of ascorbic acid treatment, quantified in (G), P = 0.03305, n = 6. (C–F) Cholesterol supplementation does not rescue hypomyelination in Fig4^Floxed/plt, P0-Cre cultures following 7 days of ascorbic acid treatment. (H) Cholesterol supplementation does not rescue hypomyelination also after 15 days of ascorbic acid treatment, as myelin segments in mutant cultures were decreased when compared with controls without cholesterol supplementation (P = 0.00071) and with cholesterol supplementation (P = 0.00868), n = 6. (H) Note that, after 15 days of cholesterol supplementation, control cholesterol-treated and untreated cultures produced the same amount of myelin, as previously reported (29). Red is MBP, myelin basic protein. Bar in (B) and (F) is 50 µm. Control genotypes are Fig4^Floxed/plt and Fig4^{Floxed/Floxed}.