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IC50 values (nM) of OTFP and TFDK as inhibitors of either wild-type or F259I MsJHE. Values are averages of triplicate IC50 measurements. Standard deviations are shown in parentheses.
| Wild Type | IC50 (nM) | F259I | IC50 (nM) |
|---|---|---|---|
| TFDK | 530 (32) | TFDK | 1,600 (150) |
| OTFP | 22 (3) | OTFP | 330 (57) |
| TFDK:OTFP | 24 | 5 |
