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. 2014 Dec 5;16(24):6334–6337. doi: 10.1021/ol503078h

Table 2. Scope of Wittig Reaction.

graphic file with name ol-2014-03078h_0008.jpg

entry 1 R2 R3 time (h) product yield (%) E/Za
1 1a –H –H 8 2a 97 3:1
2 1b –Br –H 10 2b 97 3:1
3 1c –CO2Et –H 10 2c 96 5:1
4 1d –Ph –H 8 2d 88 3:1
5 1e –H –Me 8 2e 85 4:1
6 1f –H –Et 8 2f 85 4:1
7 1g –H –Br 8 2g 93 5:3
a

E/Z values were calculated from the ratio of the integrals of the allylic methylenes in the 1H NMR spectra.