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. 2014 Dec 5;16(24):6334–6337. doi: 10.1021/ol503078h

Table 3. Alkylation of Allylic Nitrile 2a.

graphic file with name ol-2014-03078h_0009.jpg

entry electrophile product R6 yield (%)
1 MeI 4a –CH3 77
2 EtI 4b –CH2CH3 80
3 BnBr 4c –CH2Ph 75
4 allyl-Br 4d –CH2CH=CH2 67
5 propargyl-Br 4e –CH2C≡CH 72
6 BrCH2CO2Et 4f –CH2CO2Et 80