Skip to main content
. 2014 Jul 7;79(24):11885–11902. doi: 10.1021/jo501392r

Figure 7.

Figure 7

Plot of initial rate versus [THF] in Et2O (curve A) and in hexanes (curve B) cosolvent for the ortholithiation of ArH (0.050 M) by LDA (0.10 M) at −78 °C. The data were measured with IR spectroscopy. The curves depict unweighted least-squares fits to y = a[THF] ± b. Curve A: a = (−1.1 ± 0.3) × 10–7, b = (3.3 ± 0.3) × 10–6. Curve B: a = (−2.8 ± 0.3) × 10–7, b = (4.7 ± 0.3) × 10–6. The greater slope using hexanes as cosolvent compared with that using Et2O as cosolvent illustrates the influence of long-range medium effects.