Figure 4.

Quantitative region-of-interest (ROI) analysis of the PET data. Time–activity curves of the liver, tumor, blood, kidney, and muscle following intravenous injection of (A) ⁴⁴Sc–CHX-A″-DTPA–Cetuximab-Fab in U87MG tumor-bearing mice (targeted), (B) ⁴⁴Sc–CHX-A″-DTPA-denatured-Cetuximab-Fab in U87MG tumor-bearing mice (non-targeted), (C) ⁴⁴Sc–CHX-A″-DTPA–Cetuximab-Fab in U87MG tumor-bearing mice after treatment with a 2 mg blocking dose of Cetuximab (blocking), (D) ⁴⁴Sc–CHX-A″-DTPA–Cetuximab-Fab in Caco-2 tumor-bearing mice (negative control). (E) Comparison of tracer uptake in the tumors among all four groups.