Quantitative region-of-interest (ROI) analysis
of the PET data.
Time–activity curves of the liver, tumor, blood, kidney, and
muscle following intravenous injection of (A) 44Sc–CHX-A″-DTPA–Cetuximab-Fab
in U87MG tumor-bearing mice (targeted), (B) 44Sc–CHX-A″-DTPA-denatured-Cetuximab-Fab
in U87MG tumor-bearing mice (non-targeted), (C) 44Sc–CHX-A″-DTPA–Cetuximab-Fab
in U87MG tumor-bearing mice after treatment with a 2 mg blocking dose
of Cetuximab (blocking), (D) 44Sc–CHX-A″-DTPA–Cetuximab-Fab
in Caco-2 tumor-bearing mice (negative control). (E) Comparison of
tracer uptake in the tumors among all four groups.