Table 1. Genome-wide association result for the top 20 single-nucleotide polymorphisms (SNPs) in a comparison of AERD with NC.

SNP	Chr	Physical Location	Gene	Location	MAF		P value§
					AERD (n = 179)	NC (n = 1989)
rs3117230	6p21.32	33183613		intergenic	0.16	0.08	3.61E–06
rs751355	18p11.22	9418420		intergenic	0.46	0.34	4.98E–06
rs3128965	6p21.32	33163877	HLA-DPB1	downstream	0.16	0.08	6.06E–06
rs12576973	11q24.2	126763852		intergenic	0.22	0.14	9.10E–06
rs10895516	11q22.3	103113180		intergenic	0.30	0.20	9.89E–06
rs12577873	11q24.2	126767198		intergenic	0.22	0.14	1.00E–05
rs2618221	11q24.2	126757104		intergenic	0.22	0.14	1.03E–05
rs17101477	11q22.3	103111948		intergenic	0.30	0.20	1.70E–05
rs2697717	11q24.2	126709174		intergenic	0.25	0.16	1.96E–05
rs1343036	3q26.2	170724940	MECOM	Intron	0.23	0.15	2.17E–05
rs5755393	22q12.3	33607037	ISX	intergenic	0.38	0.50	3.80E–05
rs16968024	17q11.2	28465300	ACCN1	Intron	0.15	0.08	3.90E–05
rs477963	17q25.1	70153035		intergenic	0.16	0.10	4.13E–05
rs2038088	22q12.3	33595255		intergenic	0.38	0.50	4.32E–05
rs10893679	11q24.2	126786589		intergenic	0.22	0.14	4.75E–05
rs12495069	3q26.2	170703798	MECOM	Intron	0.24	0.16	5.58E–05
rs6579884	5q33.1	151016491		intergenic	0.14	0.08	5.63E–05
rs6444857	3q26.2	170721406	MECOM	Intron	0.23	0.15	5.90E–05
rs904664	12p13.33	99608	IQSEC3	5'UTR	0.06	0.03	6.46E–05
rs7934354	11p15.4	5522482	OR52H1	Exon	0.29	0.40	7.44E–05

^§Cochran–Armitage trend test.

Abbreviations: AERD, aspirin-exacerbated respiratory disease; NC, normal controls, MAF, minor allele frequency; HLA-DPB1, major histocompatibility complex, class ii, dp beta 1; ACCN1, amiloride-sensitive cation channel 1; MECOM; MDS1 and EVI1 complex locus; IQSEC3, iq motif and sec7 domain 3, OR52H1, olfactory receptor, family 52, subfamily h, member 1.