Table 2. Genetic association of the SNP, rs3128965, with AERD phenotype.

	Discovery GWAS				Replication study
	AIA	NC	AERD vs. NC		AERD	ATA	NC	AERD vs. ATA		AERD vs. NC		ATA vs. NC
	(n = 179)	(n = 1989)	P Value§	OR(95% CI)¶	(n = 264)	(n = 387)	(n = 238)	P value§	OR(95% CI)¶	P value§	OR(95% CI)¶	P value§	OR(95% CI)¶
GG	129(72.1%)	1664(83.7%)	1.40E–05	1(reference)	191(72.35%)	323(83.46%)	195(81.93%)	0.001	1(reference)	0.002	1(reference)	0.646	1(reference)
AG	44(24.6%)	313(15.7%)	2.16E–03	1.860(1.287, 2.689)	65(24.62%)	60(15.50%)	43(18.07%)	0.098	1.805(1.216, 2.680)	0.999	1.631(1.021, 2.604)	0.999	0.769(0.499, 1.268)
AA	6(3.3%)	12(0.6%)	9.70E–05	5.747(2.027, 16.293)	8(3.03%)	4(1.03%)	0(0%)	0.001	3.166(0.937, 10.703)	0.008	NA	0.462	NA

Abbreviations: AERD, aspirin-exacerbated respiratory disease; ATA, aspirin-tolerant asthma; NC, normal controls; NA; not applicable.

^§Each P-value was calculated for a co-dominant, dominant and recessive model. Logistic regression analysis was applied to control for age and gender as covariates.

^¶Odd ratio was given by co-dominant analysis model. Bold character indicates significance.