Table 3. Clinical features according to the SNP, rs3128965, in asthmatics (264 AERD and 387 ATA).
| rs3128965 | |||
| GG (n = 514) | AA+AG (n = 137) | P value§ | |
| Age (year) | 43.77±14.31 | 43.74±13.56 | 0.985 |
| Sex (female, %) ¶ | 303/514 (58.9%) | 95/137 (69.3%) | 0.030 |
| Atopy (presence, %) ¶ | 234/425 (55.1%) | 70/114 (61.4%) | 0.243 |
| Total IgE (IU/mL) | 390.59±741.4 | 336.89±413.41 | 0.480 |
| PC20, methacholine (mg/mL) | 9.64±19.2 | 6.09±10.24 | 0.037 |
| Base line FEV1 (%) | 87.09±18.65 | 88.02±18.69 | 0.806 |
| % Fall of FEV1 by aspirin challenge | 15.92±11.04 | 20.45±14.77 | 0.039 |
| Chronic rhinosinusitits (LM score 3-4, %) ¶ | 52/96 (54.2%) | 24/33 (72.7%) | 0.068 |
| Total eosinophil count (count/µl) | 455.34±940.01 | 486.18±638.24 | 0.763 |
| ECP (µg/L) | 30.8±36.98 | 34.38±36.12 | 0.470 |
| Sputum_eosinophil (%) | 22.19±34.14 | 26.66±37.55 | 0.430 |
| Sputum_neutrophil (%) | 57.02±33.65 | 59.83±34.33 | 0.683 |
| 15-HETE (pg/mL) * | 3031.9±965.3 | 3815.2±1316.1 | 0.004 |
Abbreviations: FEV1, forced expiratory volume in 1 s; IgE, immunoglobulin E; methacholine PC20, the provocative concentration of methacholine required to cause a 20% fall in FEV1; 15-HETE, 15-hydroxyeicosatetraenoic acid; ECP, eosinophil cationic protein; LM score, Lund-Mackay CT score. Values are given as n (%) for categorical variables and as mean ± SD for continuous variables.
¶
count number/valid number.
*median ± std.
§
P value were applied by Fisher exact test for categorical variable and T-test for continuous variable.
Bold character indicates significance.