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. 2014 Dec 23;9(12):e113959. doi: 10.1371/journal.pone.0113959

Figure 2. Load-induced periosteal bone formation responses are different in CGRPα wildtype and knockout mice.

Figure 2

Cyclic loading of the right ulna in wildtype mice induced adaptive responses in periosteal mineralizing surface (Ps.MS/BS), periosteal mineral apposition rate (Ps.MAR), and periosteal bone formation rate (Ps.BFR/BS). When brachial plexus anesthesia (BPA) was performed before loading, the Ps.MS/BS response to loading was significantly blocked (p<0.005). In CGRPα knockout mice, Ps.MS/BS response to loading was lost, but Ps.MAR and Ps.BFR/BS response to loading was preserved. Blocking of Ps.MAR and Ps.BFR/BS responses in the right ulna after right ulna loading was enhanced in CGRPα knockout mice, compared with wild-type mice. *p<0.05 versus left ulna in Block + Load CGRPα knockout mice. Sham – sham loaded group, Load – loaded group, Block + Load – BPA treatment before loading. n = 11–14 mice/group.