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. 2014 Dec 23;9(12):e115600. doi: 10.1371/journal.pone.0115600

Figure 5. NSCLC and breast cancer cells are not protected with CDDO-Me.

Figure 5

Clonogenic survivals show that (A) A549, (B) H2009, and (C) HCC 2429 are not protected when pretreated with the same concentration of CDDO-Me (10 nM) that protected HBEC cells. (E) Even higher concentrations of CDDO-Me are not protective of cancer cells after 3 Gy radiation, including MDA-MB-231 breast cancer line. However, 150 nM CDDO-Me significantly decreases the clonogenic survival of MDA-MD-231 cells after exposure to 3 Gy radiation. Mean ± SEM of three experiments seeded in triplicate, **p<0.01, t-test (compared to DMSO at 3 Gy).