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. 2014 Dec 23;9(12):e115648. doi: 10.1371/journal.pone.0115648

Figure 4. Mitragynine prolonged action potential duration in hiPSC-CMs.

Figure 4

(A) APs were recorded prior to and post application of 10 µM Mitragynine in ventricular-like hiPSC-CMs paced at 1 Hz. Overlay of single AP from the same cell prior to and post Mitragynine treatment (right) is presented. The table inserted below represents the AP properties. (B1) Mitragynine (10 µM) treatment resulted in sporadic early after depolarization (EAD, indicated by arrow) in hiPSC-CM paced at 0.2 Hz. (B2) Mitragynine (100 µM) treatment resulted in frequent EADs in spontaneously contracting hiPSC-CMs.