Figure 5. Mitragynine did not alter the L-type calcium current in hiPSC-CMs.
(A) Time-course in vehicle (left) and wash out of Mitragynine (right), n = 4. (B) Left: Representative I Ca,L traces prior to and post application of Mitragynine (10 µM). Pulse protocol is shown in the inset. Right: Averaged I-V relations for I Ca,L prior to and post Mitragynine. (C and D) Steady-state activation and inactivation curves of I Ca,L prior to and post Mitragynine treatment.