Table 1. Inhibition of Mitragynine and its analogues on I _Kr tail current in hiPSC-CMs.

Compounds	% inhibition	0.01 uM	0.1 uM	1 uM	10 uM	100 uM
Mitragynine	Ave	7.63%	11.48%	39.83%	53.55%	67.06%
(n = 12)	SEM	4.18%	5.37%	9.55%	6.51%	9.41%
	P value	0.0716	0.0388	0.0004	0.0000	0.0000
Paynantheine	Ave	12.21%	25.71%	32.70%	59.34%	69.91%
(n = 11)	SEM	6.79%	7.34%	6.27%	6.77%	3.09%
	P value	0.0756	0.0015	0.0000	0.0000	0.0000
Speciogynine	Ave	9.81%	21.73%	41.22%	57.24%	68.01%
(n = 13)	SEM	3.99%	6.30%	6.01%	3.30%	3.95%
	P value	0.0140	0.0032	0.0000	0.0000	0.0000
Speciociliaitine	Ave	24.52%	33.77%	42.51%	79.21%	83.74%
(n = 14)	SEM	8.28%	9.70%	5.67%	3.53%	5.74%
	P value	0.0046	0.0025	0.0000	0.0000	0.0000