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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: Immunity. 2012 Dec 6;37(6):1009–1023. doi: 10.1016/j.immuni.2012.08.027

Figure 5. NLRP1a activation prevents recovery from hematopoietic stress.

Figure 5

(A) Leukopenia induced by 150 mg/kg 5-fluorouracil in Il1r−/−Nlrp1aQ593P/Q593P mice at Day 12 but not Il1r−/− littermate controls. *p<0.05, mean ± SEM, n=3–4 mice. (B) Reticulocyte numbers 12 days following challenge with 5-fluorouracil. *p<0.05, mean ± SEM, n=4 mice. (C) Hematoxylin and eosin staining of bone marrow of Il1r−/−Nlrp1aQ593P/Q593P and Il1r−/− mice 12 days after treatment with 5-FU. (D) The composition of blood following injection with 150 mg/kg 5-fluorouracil. *p<0.05, mean ± SEM, n=8–18 mice. (E) Reticulocyte numbers 12 days following challenge with 5-fluorouracil. *p<0.05, mean ± SEM, n=8–18 mice. (F) Spleen weight at steady state or 12 days post-injection with 5-FU. *p<0.05, mean ± SEM, n=3–18 mice.