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. 2014 Dec 23;9(12):e114838. doi: 10.1371/journal.pone.0114838

Figure 8. Representative images of calbindin, parvalbumin, Hsp27 and Hsp70 in the SC 7d after ON crush.

Figure 8

A–D: Calbindin and parvalbumin labelling in the SC. The characteristic trait of calbindin immunolabelling in the SC is a band of large cell bodies that are principally localised to the stratum opticum (A, B). The distinguishing feature of parvalbumin immunolabelling in the SC is a population of smaller sized cells that are chiefly localised to the stratum griseum superficiale. The stratum opticum contains parvalbumin-positive fibres, but only scattered cells (C, D). E–H: Hsp27 labelling in the SC. Hsp27 immunoreactivity is manifest in a tight band stretching across the injured (contralateral) SC (E, F), but is negligible in the uninjured (ipsilateral) SC (G, H). I–L: Hsp70 labelling in the SC. Hsp70 immunoreactivity is uniformly low throughout the injured (contralateral; I, J) and uninjured (ipsilateral; K, L) SC. SC, superior colliculus. Scale bar: A, C, E, G, I, K = 250 µm; B, D, F, H, J, L = 50 µm.