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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Integr Biol (Camb). 2015 Jan;7(1):112–127. doi: 10.1039/c4ib00197d

Figure 7.

Figure 7

Schematic representation of the events during chondrogenesis. (A) Chondrogenesis consists of a dynamic series of events including stimulation of mesenchymal stem cells followed by mesenchymal aggregation and condensation and finally cartilage tissue differentiation and maturation. Expression pattern of specific cartilage genes at different stages of tissue development are shown. (B) Overview of the effect of specific growth factors on zonal organization of the articular cartilage tissue including superficial, middle/deep and calcified cartilage zones. The spatial distribution of specific growth factors in each zone is illustrated. The distribution of cartilage specific proteins is indicated by gradients of gene expression. 2, 59 PC, PHC, and HC stand for pre-chondrocytes, pre-hypertrophic chondrocytes, and hypertrophic chondrocytes, respectively.