Table 2.
Adjusted risk of adverse pregnancy outcomes in female survivors of childhood cancer
| Preterm birth (N=310) |
Stillbirth (N=21) |
Miscarriageb (N=397) |
Risk of Miscarriage by Uterine Radiationc | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| 0–2.5 Gy (N=1,703) |
> 2.5 Gy (N=149) |
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|
|
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| N | Row % | RR (95% CI) | Row % | RR (95% CI) | Row % | RR (95% CI) | Row % | RR (95% CI) | Row % | RR (95% CI) | |
| Physically inactivea | |||||||||||
| Yes | 916 | 22.6 | 0.9 (0.6, 1.2) | 0.7 | 0.5 (0.1, 1.8) | 22.6 | 1.0 (0.8, 1.4) | 22.8 | 1.1 (0.8, 1.5) | 21.1 | 0.5 (0.2, 1.5) |
| No | 835 | 26.2 | 1.0 | 1.4 | 1.0 | 21.3 | 1.0 | 20.8 | 1.0 | 28.1 | 1.0 |
| Body Mass Index (kg/m2) | |||||||||||
| Underweight: <18.5 | 114 | 18.3 | 1.0 (0.5, 2.1) | 1.8 | 1.3 (0.1, 17.9) | 18.4 | 0.8 (0.4, 1.4) | 18.8 | 0.9 (0.5, 1.6) | 15.4 | 0.2 (0.1, 0.7) |
| Normal weight: 18.5–25 | 1,056 | 22.7 | 1.0 | 0.7 | 1.0 | 21.2 | 1.0 | 21.1 | 1.0 | 23.5 | 1.0 |
| Overweight: 25–30 | 321 | 27.9 | 1.3 (0.9, 1.9) | 2.2 | 2.3 (0.5, 10.9) | 20.9 | 0.9 (0.6, 1.3) | 20.6 | 0.8 (0.5, 1.2) | 24.0 | 0.5 (0.1, 1.8) |
| Obese: ≥30 | 205 | 31.5 | 1.1 (0.7, 1.8) | 0.5 | 0.8 (0.1, 7.9) | 28.8 | 1.4 (0.8, 2.1) | 28.6 | 1.3 (0.8, 2.0) | 35.7 | 1.5 (0.4, 6.3) |
| Global distress | |||||||||||
| Yes | 116 | 20.3 | 0.8 (0.4, 1.7) | 1.7 | 1.3 (0.1, 10.9) | 20.9 | 1.5 (0.9, 2.5) | 28.4 | 1.6 (0.9, 2.7) | 28.6 | 0.9 (0.3, 3.0) |
| No | 1,347 | 24.5 | 1.0 | 0.7 | 1.0 | 28.4 | 1.0 | 20.9 | 1.0 | 21.6 | 1.0 |
| Smoking (pack-years) | |||||||||||
| 0 (Never) | 1,286 | 24.8 | 1.0 | 1.2 | 1.0 | 20.3 | 1.0 | 20.3 | 1.0 | 21.2 | 1.0 |
| 0–5 | 293 | 21.4 | 0.7 (0.5, 1.2) | 1.4 | 1.2 (0.3, 5.2) | 21.2 | 1.1 (0.7, 1.6) | 21.3 | 1.1 (0.8, 1.7) | 20.0 | 0.7 (0.3, 1.9) |
| > 5 | 133 | 35.1 | 1.6 (0.8, 3.0) | 0.8 | 1.4 (0.1, 16.1) | 34.6 | 2.2 (1.4, 3.5) | 31.2 | 1.9 (1.2, 3.0) | 87.5 | 53.9 (2.2, 1326.1) |
Risk presented as odds ratio (95% confidence interval); Models adjusted for age at pregnancy, age at diagnosis, educational attainment, and parity
a
< 60 minutes vigorous or < 150 minutes moderate physical activity per week
b
In a multivariable model evaluating risk for miscarriage, Pinteraction for smoking*uterine radiation = 0.01
c
In a multivariable model adjusted for age at pregnancy, age at diagnosis, educational attainment, parity, inactivity, BMI, global distress, and smoking, the risk for miscarriage among those who were exposed to > 2.5 Gy of radiation was 1.2 (95% CI 0.8, 1.9).