Table 1.
Experimental protocols and results for two well-explored CCO models
| Tumor type | Cre driver Cell type | Oncogenes/tumor suppressors lineage tracer | CCO | Refs |
|---|---|---|---|---|
| BCC | K14Cre-ER ShhCre-ER K15Cre-ER |
Rosa-LSL-SmoM2 | Interfollicular epidermis | Youssef et al Nature Cell Biology 2010 |
| K15Cre-PR K14Cre-ER |
Ptch1+/1 + Ionizing Radiation+ LSY-YFP +p53 KO |
HFSCs HFSCs and interfollicular epidermis |
Wang et al Cancer Cell 2011 |
|
| K15Cre-PR Lgr5Cre-ER K5Cre-ER |
Rosa-LSL-rtTA tetO-Gli2deltaN |
HFSCs = nodular BCC Interfollicular epidermis = superficial BCC |
Grachtchouk et al JCI 2011 |
|
| K15Cre-PR | Rosa-LSL-SmoM2 + wounding |
HFSCs | Wong et al PNAS 2011 |
|
| K5Cre-tTA K5Cre-PR Lgr5Cre-ER |
TRE-Gli1 Ptch1 flox/flox Ptch1 flox/flox |
Interfollicular epidermis HFSCs only when wounded |
Kasper et al PNAS 2011 |
|
| Intestinal Adenoma | Cd133Cre-ER | Activated β-catenin | Crypt stem cells | Zhu et al Nature 2009 |
| Lgr5Cre-ER AH-Cre |
APC KO | Crypt stem cells | Barker et al Nature 2009 |
|
| Xbp1sCre-ER | Activated β-catenin and IkB-α KO or KrasG12D |
Differentiated cells via dedifferentiation | Schwitalla et al Cell 2013 |