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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Microvasc Res. 2014 Oct 28;97:167–180. doi: 10.1016/j.mvr.2014.10.008

Fig 2. Effect of BRE on leukocyte adhesion in HEMEC and HIMEC.

Fig 2

As expected, both HEMEC and HIMEC tightly adhere to U937 cells, which was increased with TNF-α and IL-1β activation. 2A). a- resting HEMEC bound low levels of U937, b-BRE had no affect on resting HEMEC, c- TNF-α/IL-1β activation increased HEMEC-U937 adhesion, d- BRE inhibited U937 binding to TNF-α/IL-1β-activated HEMEC. B). e- resting HIMEC bound low levels of U937, f- BRE treatment modestly increased the leukocyte binding in resting HIMEC, g- TNF-α/IL-1β- increased HIMEC-U937 adhesion, h- BRE treatment of TNF-α/IL-1β HIMEC drastically enhanced the U937 binding. C & D represent the quantification of enhanced leukocyte binding by TNF-α/IL-1β in both HEMEC and HIMEC, which was decreased by BRE in HEMEC, but not HIMEC. Experiments were done in triplicate, and the data are expressed as means ± SD. An asterisk denotes a significant difference in mean intensity between control and treated cells.

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