Table 2.
Comparisons of Inflammatory Markers in the Maternal Circulation at Admission, Admission+2hrs, and Admission+4hrs between Low-Risk Nulliparous Women Admitted in Pre-Active or Active Labor (N = 118)
| Pre-Active Labor (n = 63) | Active Labor (n = 55) | |||||
|---|---|---|---|---|---|---|
| n | n | p | ||||
| Neutrophils | admission | 61 | 9.28 (4.07–19.51) | 55 | 10.76 (6.02–20.04) | 0.030 |
| +2 hours | 54 | 9.63 (3.83–22.73) | 51 | 12.00 (7.23–23.11) | < 0.001 | |
| +4 hours | 49 | 10.54 (4.69–23.15) | 46 | 12.91 (7.82–23.31) | < 0.001 | |
| Monocytes | admission | 61 | 0.75 (0.30–2.31) | 55 | 0.72 (0.38–1.82) | 0.866 |
| +2 hours | 54 | 0.71 (0.12–1.35) | 51 | 0.69 (0.22–1.63) | 0.850 | |
| +4 hours | 49 | 0.70 (0.34–1.26) | 46 | 0.64 (0.34–1.38) | 0.826 | |
| IL-1β | admission | 63 | 0.51 (0.00–10.61) | 55 | 0.58 (0.00–3.32) | 0.352 |
| +2 hours | 58 | 0.49 (0.00–4.01) | 53 | 0.50 (0.00–3.10) | 0.906 | |
| +4 hours | 56 | 0.48 (0.00–4.50) | 49 | 0.50 (0.00–2.87) | 0.916 | |
| IL-6 | admission | 63 | 2.9 (0.8–63.9) | 55 | 5.1 (1.4–30.8) | 0.002 |
| +2 hours | 58 | 3.6 (1.3–26.7) | 53 | 6.9 (1.9–39.4) | < 0.001 | |
| +4 hours | 56 | 5.2 (1.7–86.2) | 49 | 9.9 (2.3–46.8) | < 0.001 | |
| IL-8 | admission | 63 | 5.7 (1.2–16.6) | 55 | 5.5 (1.8–96.5) | 0.728 |
| +2 hours | 58 | 5.8 (2.1–17.2) | 53 | 5.7 (2.1–27.7) | 0.468 | |
| +4 hours | 56 | 6.3 (1.9–14.6) | 49 | 5.3 (1.9–16.3) | 0.318 | |
| TNF-α | admission | 63 | 6.8 (1.9–34.7) | 55 | 6.8 (1.9–25.8) | 0.861 |
| +2 hours | 58 | 7.2 (2.4–33.3) | 53 | 6.5 (1.8–25.2) | 0.189 | |
| +4 hours | 56 | 7.7 (2.6–33.4) | 49 | 6.1 (1.6–27.1) | 0.191 | |
| IL-10 | admission | 63 | 3.6 (0.4–78.5) | 55 | 5.2 (0.6–70.5) | 0.003 |
| +2 hours | 57 | 3.6 (0.7–27.9) | 53 | 7.3 (1.6–132.8) | < 0.001 | |
| +4 hours | 55 | 3.4 (0.7–28.6) | 49 | 6.8 (0.7–70.5) | 0.001 | |
Median (Range). Mann-Whitney U tests. Leukocytes (absolute) x 1000/µL. Cytokines in pg/mL. The number of research participants sampled for blood at each biomarker collection time point varies because blood was collected only if the woman was still in labor at the sampling time point and because a few sampling time points were inadvertently missed by research team members. Holm’s sequential rejective multiple test procedure was applied to sequentially determine significant p-values, i.e., for 21 tests, the most significant p-value must be smaller than 0.05/21 = 0.0024, the second most significant p-value must be smaller than 0.05/20 = 0.0025, the third most significant p-value must be smaller than 0.05/19 = 0.0026, etc.