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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Oncogene. 2014 Jun 23;34(17):2204–2214. doi: 10.1038/onc.2014.168

Figure 1. miR-124 levels inversely correlate with hypoxia signatures in glioblastoma patients and are further decreased in pseudopalisading necrotic regions within patient tissues.

Figure 1

(a) Hypoxia Inducible Factor (HIF) metagene correlation to miRNA levels. MiRNAs that are positively and negatively correlated with the metagene are indicated blue = p - value < 0.05. Red dot = miR-124. (b) HIF metagene in TCGA GBM patient samples divided into high and low miR-124 / miR-210 levels. (c) Schematic of Laser-Capture Microdissection. Top: region of pseudopalisading necrosis. The inner necrotic region is discarded, while the pseudopalisade is collected as “hypoxic tissue”. Bottom: Non-necrotic region, collected as the perfused (“normoxic”) tissue counterpart. (d) miR-124 and GLUT1 mRNA levels in perfused or “normoxic” and hypoxic regions in patient samples. Top: averages; bottom: paired representation (each pair is from an individual patient). * p - value = 0.047 (miR-124 changes); p - value = 0.035 (GLUT1 changes). n = 4 patients.