Table 3.
Dose-response relationship of Δ minutes spent in moderate-to-vigorous physical activity with endpoints.a
| Characteristics | Intervention group | P for trend | |||
|
|
Low (n=36) | Middle (n=36) | High (n=36) |
|
|
| Baseline moderate-to-vigorous activity |
|
|
|
|
|
|
|
Mean (SD) | 22.5 (17.9) | 17.3 (16.5) | 19.0 (14.9) | .38 |
|
|
Range | 2.4 to 87.2 | 0.8 to 92.0 | 2.4 to 62.4 |
|
| Δ minutes moderate-to-vigorous activity |
|
|
|
|
|
|
|
Mean (SD) | –6.75 (8.20) | 5.91 (3.56) | 34.27 (21.52) |
|
|
|
Range | –25.8 to 1.60 | 1.70 to 14.2 | 15.8 to 117.6 |
|
| Successful participants, n | 11 | 12 | 26 | .001 | |
| Clinical parameters (mean Δ, SE) |
|
|
|
|
|
|
|
Weight (kg) | –0.93 (0.35) | –0.64 (0.44) | –2.85 (0.51) | .004 |
|
|
BMI (kg/m2) | –0.34 (0.12) | –0.23 (0.15) | –0.88 (0.17) | .02 |
|
|
Waist circumference (cm) | –1.58 (0.52) | –1.92 (0.67) | –3.69 (0.72) | .03 |
|
|
Fat percentage | –0.46 (0.48) | –0.44 (0.35) | –0.94 (0.43) | .43 |
| Cardiovascular disease risk (mean Δ, SE) |
|
|
|
|
|
|
|
Framingham risk score (%) | 0.43 (0.46) | –0.78 (0.52) | –1.28 (0.76) | .045 |
| Biochemistry (mean Δ, SE) |
|
|
|
|
|
|
|
Glucose (mmol/L) | –0.23 (0.10) | –0.15 (0.09) | –0.21 (0.07) | .94 |
|
|
Ln insulin (mU/L) | –0.14 (0.07) | –0.06 (0.08) | –0.26 (0.08) | .20 |
|
|
HbA1c (%) | –0.04 (0.02) | –0.03 (0.02) | –0.07 (0.02) | .20 |
|
|
Ln HOMA index | –0.18 (0.08) | –0.09 (0.08) | –0.30 (0.08) | .26 |
|
|
Total cholesterol (mmol/L) | –0.29 (0.08) | –0.10 (0.10) | –0.40 (0.11) | .63 |
|
|
HDL cholesterol (mmol/L) | –0.10 (0.04) | 0.01 (0.04) | 0.05 (0.03) | .007 |
|
|
Ln triglycerides (mmol/L) | 0.003 (0.05) | –0.06 (0.05) | –0.22 (0.07) | .02 |
|
|
LDL cholesterol (mmol/L) | –0.19 (0.06) | –0.09 (0.08) | –0.27 (0.09) | .61 |
|
|
Cholesterol/HDL ratio | 0.006 (0.08) | –0.15 (0.11) | –0.48 (0.17) | .02 |
|
|
Ln C-reactive protein (mg/L) | –0.11 (0.10) | –0.17 (0.13) | –0.23 (0.17) | .66 |
a P for trend was calculated with linear regression. P for trend was adjusted for sex and age, except for Framingham risk score for which age and sex are integrated.