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. 2014 Dec 15;3(12):e133. doi: 10.1038/oncsis.2014.45

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Copyright © 2014 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Identification of kinases whose inhibition preferentially blocks the proliferation of HER2+ breast cancer cell lines. (a) Heatmap of unbiased selection of siRNAs that differ in their effects on HER2+ and non-HER2-amplified breast cancer cell lines (comprehensive screen). CMS based on HER2 status was performed using Gene Pattern software. Only statistically significant effects are shown (P<0.01, permutation test, median T-test). Supervised hierarchical clustering analysis of siRNAs and cell lines was performed using Cluster 3.0 software (Michael Eisen). Data were visualized using Java TreeView. (b) Waterfall plots of the indicated kinases from (a) whose siRNA-mediated inhibition selectively blocked the proliferation of HER2+ cell lines (pink bars). (c) Gene enrichment analysis (DAVID) of siRNA-targeted genes identified in a. Analysis was performed as for Figure 2c.