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. 2014 Dec 8;3(12):e131. doi: 10.1038/oncsis.2014.47

Figure 1.

Figure 1

(a) Sulforaphane causes a global decrease in H3K9-trimethylation in PC3 cells. H3K9me3 was decreased relative to global histone H3 at 6 and 12 h post treatment (P<0.01 by two-way analysis of variance (ANOVA) with Bonferroni post test, mean+s.e.m. for three independent experiments). (b) Representative blot from one of three independent experiments at 12 h post treatment. (c) SUV39H1 is increased at 6 h post treatment (P<0.05 by two-way ANOVA with Bonferroni post test, mean+s.e.m. for three independent experiments). The early increase in SUV39H1 was not maintained, with the protein returning to control level by 12 h. (d) Representative blots from one of three independent experiments at 12 h post treatment. β-Actin was probed as a loading control. SFN, sulforaphane.