Table 3.

Result of Genome-Wide Association Study for smoking initiation and nicotine dependence for total and male samples in discovery stage

Sample	Phenotype	Chr.	SNP ID	Related gene	Allelesa	AF	KARE discovery
						KARE	OR	p value*
Total	SI-1	15	rs1442815	-	G/A	0.44	1.254	4.10 × 10−6
	SI-2	5	rs11134474	-	A/G	0.04	0.645	4.60 × 10−6
	ND	7	rs1404697	-	C/G	0.13	1.384	3.19 × 10−6
		7	rs848353	-	T/C	0.13	1.37	5.43 × 10−6
Male	SI-1	9	rs10511914	DCAF12	T/C	0.28	0.757	4.23 × 10−6
	SI-2	6	rs7761503	RGS17	T/C	0.43	0.833	9.46 × 10−6
		6	rs7747583	RGS17	C/A	0.43	0.833	9.96 × 10−6
		6	rs2349433	RGS17	G/A	0.43	0.831	8.19 × 10−6
		7	rs1385706	-	G/A	0.32	1.221	6.69 × 10−6
		7	rs12534697	-	G/C	0.32	1.219	7.12 × 10−6
	ND	7	rs1404697	-	C/G	0.13	1.411	4.63 × 10−6
		7	rs848353	-	T/C	0.13	1.401	6.40 × 10−6
		7	rs12536963	EXOC4	T/G	0.29	1.29	5.92 × 10−6
		10	rs4424567	FRMD4A	G/A	0.46	1.249	9.90 × 10−6

AF allele frequency; the frequency is for the minor allele in KARE sample, OR odds ratio

^*Additive model

^aMajor/minor alleles in KARE