Table 4.

Result of replication and meta-analysis for smoking initiation and nicotine dependence for total and male samples

Sample	Chr	rs ID	Related gene	Allele*	AF		Pheno-type	Replication		Meta-analysis p value
					EA	AA		EA	AA	KARE + EA	KARE + AA	KARE + EA + AA
Total	15	rsl442815	-	G/A	0.3	0.18	Age onset	4.37 × 10−1 r	9.22 × 10−1 r	2.55 × 10−5	5.10 × 10−5	1.70 × 10−4
	5	rs11134474	-	A/G	0.01	0.12		−1.92 × 10−1 a	−5.69 × 10−2 r	1.32 × 10−5	4.23 × 10−6	7.99 × 10−6
	7	rs1404697	-	C/G	0.05	0.05	CPD	1.98 × 10−1 a	−1.45 × 10−1 r	9.65 × 10−6	7.21 × 10−6	1.36 × 10−5
							HSI	2.66 × 10−1 a	−6.06 × 10−1 r	1.27 × 10−5	3.18 × 10−6	8.16 × 10−6
							FTND	1.66 × 10−1 a	−5.37 × 10−2 r	8.18 × 10−6	2.84 × 10−6	4.82 × 10−6
	7	rs848353	-	T/C	0.06	0.32	CPD	−3.17 × 10−1 r	4.57 × 10−3 d	2.46 × 10−5	4.59 × 10−7	1.52 × 10−6
							HSI	−3.17 × 10−1 r	2.63 × 10−3 d	2.46 × 10−5	2.72 × 10−7	9.27 × 10−7
							FTND	−3.17 × 10−1 r	8.35 × 10−4 d	2.46 × 10−5	9.16 × 10−8	3.29 × 10−7
Male	9	rs10511914	DCAF12	T/C	0.74	0.64	Age onset	3.97 × 10−1 r	6.67 × 10−1 d	2.40 × 10−5	3.89 × 10−5	1.22 × 10−4
	6	rs7761503	RGS17	T/C	0.72	0.48		7.84 × 10−2 r	−3.43 × 10−1 r	1.12 × 10−5	4.43 × 10−5	3.34 × 10−5
	6	rs7747583	RGS17	C/A	0.72	0.48		−4.09 × 10−2 r	−3.54 × 10−1 r	6.40 × 10−6	4.78 × 10−5	2.03 × 10−5
	6	rs2349433	RGS17	G/A	0.72	0.48		−4.29 × 10−2 r	−6.61 × 10−1 r	5.57 × 10−6	7.11 × 10−5	3.09 × 10−5
	7	rs1385706	-	G/A	0.16	0.19		3.75 × 10−1 a	−2.27 × 10−1 d	3.49 × 10−5	2.19 × 10−5	6.76 × 10−5
	7	rs12534697	-	G/C	0.15	0.13		3.96 × 10−1 a	3.13 × 10−1 r	3.89 × 10−5	3.12 × 10−5	9.89 × 10−5
	7	rs1404697	-	C/G	0.05	0.05	CPD	4.67 × 10−1 a	−4.91 × 10−1 a	3.04 × 10−5	3.18 × 10−5	1.16 × 10−4
							HSI	5.57 × 10−1 a	−6.90 × 10−1 a	3.58 × 10−5	4.36 × 10−5	1.81 × 10−4
							FTND	6.99 × 10−1 a	−6.62 × 10−1 a	4.41 × 10−5	4.20 × 10−5	2.13 × 10−4
	7	rs848353	-	T/C	0.06	0.32	CPD	7.23 × 10−1 a	−1.14 × 10−1 r	6.15 × 10−5	1.10 × 10−5	6.33 × 10−5
							HSI	5.65 × 10−1 a	−2.40 × 10−1 r	4.89 × 10−5	2.21 × 10−5	9.75 × 10−5
							FTND	4.84 × 10−1 a	−4.32 × 10−1 r	4.24 × 10−5	3.82 × 10−5	1.42 × 10−4
	7	rs12536963	EXOC4	T/G	-	-	-	-	-	-	-	-
	10	rs4424567	FRMD4A	G/A	0.73	0.83	CPD	1.38 × 10−2 a	−7.45 × 10−1 r	2.30 × 10−6	9.45 × 10−5	1.49 × 10−5
							HSI	1.51 × 10−2 a	5.62 × 10−1 d	2.50 × 10−6	7.29 × 10−5	1.26 × 10−5
							FTND	4.75 × 10−2 a	4.09 × 10−1 d	7.32 × 10−6	5.43 × 10−5	2.62 × 10−5

AF allele frequency; the frequency is for the minor allele in KARE

*

-: These SNPs showed a protective effect in replication study

^aAdditive

^ddominant, and

^rrecessive models were used in the association