Fig. 2.

Intradermal injection of unmodified and "self-delivery" siRNAs mediate in vivo inhibition of Luc2p activity. (a) FLG-luc2p^+/− mouse hindpaws (6 animals/group) were intradermally injected with PBS, native-siRNAs, or self-delivery modified Accell™-siRNAs on Day 0 (noted with *). Left paws were treated with siLUC2P-2 (300 pmol) and right paws with NSC4 (300 pmol). 40 µl PBS was injected into both paws of PBS control group. Representative images are shown here (see Supplementary Fig. 2, 3 and 4 for full dataset). (b) Graph depicts the average %L/R ratio for each cohort over the 7-day time-course and the error bars represent standard deviation of the mean.