Fig. 3.

Injectin augments native siRNA-mediated luciferase inhibition in vivo. (a) Hindpaws of FLG-luc2p^+/− mice (3 animals/group) were intradermally injected with PBS, native siRNAs, Invivofectamine^® 2.0-complexed native-siRNAs or Injectin-complexed native-siRNAs on Day 0 (noted with *). Left paws were treated with siLUC2P-2 (60 pmol) and right paws with NSC4 (60 pmol). 40 µl PBS was injected into both paws of PBS control group. Representative images are shown here (see Supplementary Fig. 6 for full dataset). (b) Graph depicts the average %L/R ratio for each cohort over the time-course and the error bars represent standard deviation of the mean.