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. 2014 Dec 15;5:5340. doi: 10.1038/ncomms6340

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(a) Promiscuous interactions between the IL-1 family agonists and IL-37 with the receptor molecules. Except IL-18, all agonists employ IL-1RAcP as a co-receptor, while IL-18 uses IL-18Rβ. (b) Certain regions of the receptor multiple sequence alignments manifest the unique qualities of IL-1R family IL-18Rs. The full set of sequence alignments is in Supplementary Fig. 1. (c) Structural comparison of D1 and (d) D2 of the receptors from the signalling complex. The green circles in (c) show the disulfide bond positions.