. 2014 Dec 1;20(12):1103–1120. doi: 10.1089/tmj.2014.0030

Table 2.

Summary of Weight Management Clinical Trials

STUDY (YEAR): DESCRIPTION	SAMPLE	INTERVENTION/CONTROL	OUTCOME MEASURES	ANALYSIS/RESULTS	RISK OF BIAS SCORE
Web site
Brindal et al.¹² (2012): 12-week study comparing three Web-based functional groups on retention and weight loss	n=2,648→435; 83.4% female; mean age, 45 years, mean BMI, 34.0 kg/m²	All groups used a Web site with varying features depending on three functional groups: (1) information-based (static, noninteractive version of weight loss program); (2) supportive (social, interactive Web site; social networking, dietary information); (3) personalized supportive (same as supportive but with a personalized meal planner)	Primary outcomes: retention and weight loss	Retention: 40% loss after Week 1, 20% per week lost Weeks 2–12; 5.2% of users had activity in Week 12. Weight loss: n=435; lost 4.1% of initial body weight, 37.6% lost over 5% of their body weight. Information-based: lost 4.15% (±4.26%) Supportive: lost 4.22% (±4.34%) Personalized supportive: lost 3.97% (±3.73%)	7
Cussler et al.¹³ (2008): a 12-month Internet or self-directed intervention to compare weight regain in perimenopausal women following weight loss treatment	n=135; 100% female; average age, 48.2 years; mean BMI, 30.7 kg/m²	Internet group: use of Web site for information, completion of logs (weight, diet, exercise) Self-directed group: no contact with staff	Primary outcome: weight regain at 12 months	Weight regain: Internet, 0.4±5.0 kg; self-directed, 0.6±4.0 kg (p=0.5)	6
Lachausse¹⁴ (2012): 12-week weight loss study comparing three conditions, My Student Body program, an on-campus weight management course, and a control condition	n=358±312 My Student Body: 78.3% female; 53.8% Hispanic; mean age, 26.6 years; 9.2% enrolled in PE course; n=106 On-campus course: 75.7% female; 38.6% Hispanic; mean age, 25.0 years; 10.8% enrolled in PE course; n=70 Control: 73.5% female; 39.0% Hispanic; mean age, 22.8 years; 6.9% enrolled in PE course; n=136	My Student Body (online): Internet-based program, provides nutrition and physical activity education, three information links, four rate myself links, and four main learning modules On-campus: The course met one time per week for 2 h for the entire 12 weeks and taught weight management, time management, eating behaviors, etc. Control: no intervention	Primary outcome: BMI Secondary outcomes: fruit and vegetable consumption, aerobic exercise, exercise self- efficacy, attitudes toward exercise, stress, fruit and vegetable self-efficacy	BMI: no change in BMI among the three groups Fruit and vegetable consumption: mean increased for the online group but not the other two groups from pre-test to post-test. Aerobic exercise: no change in frequency among the three groups Exercise self-efficacy: no changes in the three groups Stress: Perceived stress scale scores decreased in the online group but did not change in the other two groups. Attitudes toward exercise: no changes in the three groups Fruit and vegetable self-efficacy: scores increased in the online group, but no change in the other two groups.	4
Touger-Decker et al.¹⁵ (2010): 12-week workplace intervention for weight loss comparing an in-person versus online version	n=137±113; 93.4% female; 54% nonwhite; mean age, 46.5 years; 66.4% obese	All subjects: 90-min meeting with RD for baseline In-person: weighed weekly after education sessions Online: weekly education sessions over the Internet, asynchronous discussion board available	Primary outcome: change in body weight Secondary outcomes: waist circumference, blood pressure, physical activity, nutrient intake, quality of life	Weight loss: Weight loss within subjects was significant over time. Waist circumference: significant decrease in all subjects over 12 weeks Blood pressure: significant decrease in SBP in both groups Diet: significant reduction in calorie intake over time for all subjects Quality of life: significant decrease in number of physically and mentally unhealthy days in both groups Physical activity: increased in both groups	5
Web site plus e-mail, phone, or texting
Appel et al.¹⁶ (2011): 24-month remote and in person behavioral weight loss intervention	n=415→392; 63.6% women; 41.0% African American; mean age, 54 years Control: 63.8% women; 42.8% African American; mean age, 52.9 years Remote support: 63.3% women; 37.4% African American; mean age, 55.8 years In-person support: 63.8% women; 42.8% African American; mean age, 53.3 years	Intervention: Remote support: weekly contact for first 3 months, monthly contact for remaining durations. Participants provided with support remotely through e-mail, telephone, and Web site support. In-person support: weekly sessions first 3 months, three contacts per month for next 3 months, two monthly contacts for remaining duration. Participants had group and individual sessions plus the e-mail, telephone, and Web site support. Control: met with a weight-loss coach at the time of randomization and, if desired, at 24 months. Received brochures and a list of recommended Web sites promoting weight loss	Primary outcome: change in weight at 24 months Secondary outcomes: percentage of weight change from baseline, percentage of participants without weight gain, percentage of participants who lost at least 5% of their initial weight	Change in weight at 24 months: remote support, −4.6 ± 0.7 kg (p<0.001); in-person support, −5.1±0.8 kg (p<0.001); control, −5.1±0.8 kg Percentage weight change: remote support, −5.0%; in-person support, −5.2%; control, −1.1% Percentage with no weight gain: remote support, 77.1% (p<0.001); in-person support, 74.4% (p<0.001); control, 52.3% Percentage with 5% weight loss: remote support, 38.2% (p<0.001); in-person support, 41.4% (p<0.001); control, 18.8%	7
Bennett et al.¹⁷ (2010): 12-week Web-based intervention for obese patients with hypertension	n=101±85; 47.5% female; 30.7% African American; mean age, 54.4 years Intervention: n=51±43; 41.2% female; 37.3% African American; mean age, 54.4 years Control: n=50±42; 54% female; 24% African American; mean age, 54.5 years	Both groups received “Aims for Healthy Weight” materials from the National Heart, Lung and Blood Institute. Intervention: four counseling sessions (two in-person and two telephone) and use of a comprehensive tailored Web site with behavior change goals for weight loss Control: UC, providers approached weight loss as they saw fit	Primary outcome: weight loss at 12 weeks Secondary outcomes: change in BMI, blood pressure control (<140/90 mm Hg), and waist circumference	Weight loss: intervention, −2.71 kg; control, 0.34 kg; difference between condition (95% CI), −3.05 (−4.24, −1.85) Change in BMI: intervention, −0.94±1.16 kg/m²; control, 0.13±0.75 kg/m²; mean difference (95% CI), −1.07 kg/m² (−1.49, −0.64) No group differences for waist circumference or blood pressure	8
Chambliss et al.¹⁸ (2011): 12-week weight management intervention using computer self-monitoring and feedback with and without an enhanced behavioral component	n=120±95; 83% female; 73% white; mean age, 45.0 years	Basic group: 1-h weight management seminar, daily self-monitoring (BalanceLog software), calorie goals, weekly structured e-mail feedback, monthly measurement visits Enhanced group: calorie goals, 2-h seminar on weight management and behavior change, daily self- monitoring (BalanceLog software), weekly behavior tracking forms, step counters, monthly newsletters, monthly telephone consultations, weekly structured e-mail feedback, monthly measurement visits Wait-list control: basic intervention after 12 weeks, monthly measurement visits	Primary outcome: weight change Secondary outcomes: waist circumference, SBP	Weight change: basic, −2.7±3.3 kg; enhanced, −2.5±3.1 kg; control, +0.3±2.2 kg (no significant difference between the two treatment groups, p=0.61) Waist circumference: basic, −3.4±4.6 cm; enhanced, −2.8±5.4 cm; control, −0.6±5.2 cm (basic group was statistically different from control, p=0.04) SBP, basic, −5.9±8.6 mm Hg; enhanced, −6.0±8.2 mm Hg; control, −2.5±8.2 mm Hg (the two treatment groups had a significant decrease from baseline, p<0.001)	6
Collins et al.¹⁹ (2012): 12-week weight loss program comparing a basic Web-based program with an enhanced Web-based program	n=309±260; 41.8% male; 90.6% Australian born; mean BMI, 32.3 kg/m²	Basic: use of a Web-based weight loss program that was commercially available, including food and exercise diary, menu plans, community forums, newsletters, etc. Enhanced: Same features as basic plus personalized electronic feedback, reminder schedule, and automated personalized goals Control: wait-list control group with no access to weight loss program	Primary outcome: change in BMI, weight Secondary outcomes: change in waist circumference, lipids, glucose, insulin, blood pressure, dietary intake, and physical activity	BMI: basic, −0.72 kg/m² (1.07); enhanced, −0.98 kg/m² (1.38); control, 0.15 kg/m² (0.82); enhanced and basic versus control, p<0.001 Weight: basic, −2.14 kg (3.32); enhanced, −2.98 kg (4.05); control, 0.36 kg (2.33); enhanced and basic versus control, p<0.001 Waist circumference: basic, −2.63 cm (3.99); enhanced, −3.18 cm (5.00); control, 0.26 cm (3.10); enhanced and basic versus control, p<0.001 Lipids: significant improvement in total cholesterol when comparing enhanced with control; no other significant changes in lipids. Blood pressure: significant change in systolic BP comparing enhanced with control (95% CI, 1.31, 7.17) Dietary intake: Enhanced group decreased intake more than control (p=0.03). Physical activity: no significant changes in METs; significant increase in step count comparing enhanced with control (p=0.005)	9
Gold et al.²⁰ (2007): 12-month weight loss and weight maintenance study comparing a commercial self-help Web site (eDiets) with an online behavioral intervention (VTrim)	n=185±88 VTrim: 77% female; 98% white; mean age, 46.5 years; n=62±40 eDiets: 86% female; 98% white; mean age, 48.9 years; n=62±48	VTrim: 6-month online therapist led weight loss program with weekly lessons, meetings, and feedback and tracking of dietary intake and weight; 6-month maintenance phase included same features but less frequent (biweekly meetings) eDiets: access to the eDiets.com Web site where participants self-guided and used the Web site; provided a meal plan, calorie plan, and recipes and encouraged exercise	Primary outcome: body weight change Secondary outcomes: dietary intake, exercise, use of Web site features, eating behaviors, social influence components	Change in weight: VTrim lost more weight than eDiets in the first 6 months (6.8±7.8 kg versus 3.3±5.8 kg, p=0.005). At 12 months, VTrim had maintained significantly higher weight loss than eDiets (5.1±7.1 kg versus 2.6±5.3 kg, p=0.034). Diet and exercise: Both groups changed over time, decreased calories by 457 kcal/day for both groups, and increased exercise by 372 kcal/day from 0 to 6 months. Usage of Web site: Significantly more log-ins (0–6 months) for VTrim versus eDiets (p<0.001), more self-reported weight for VTrim versus eDiets (p=0.002) Eating behavior: Mean change in score was significantly higher for VTrim than eDiets (5.5±4.0 versus 3.2±3.8; p=0.005), indicating more behaviors conducive to weight control for VTrim. Social influence: perceived social support higher in VTrim versus eDiets (6.7±3.2 versus 3.5±2.9; p<0.001)	5
Gabriele et al.²¹ (2011): 12-week weight loss program comparing directive and nondirective electronic coaching	n=104→96 Nondirective: 80% female; 77.1% white; mean age, 42.91 years Directive: 85.70% female; 60% white; mean age, 46.57 years Minimal: 85.3% female; 76.47% white; mean age, 46.76 years	Nondirective: weekly lesson e-mails, coach supported, individual to set goals, and weekly feedback Directive: weekly lesson e-mails, coach-set goals for participant, topics of discussion selected by coach, provided concrete, specific advice Minimal support: weekly lesson e-mail, no other support	Primary outcome: weight change	Weight change: Minimal: females, −2.44 kg (3.04); males, −6.67 kg (5.32) Directive: females, −4.50 kg (3.73); males, −3.35 kg (5.88) Nondirective, females, −2.50 kg (3.36); males, −6.57 kg (6.63) Significance: minimal versus directive for females, p=0.01; nondirective versus directive for females, p=0.00	7
Hersey et al.¹⁰ (2012): 15–18-month weight management program comparing three interventions with increasing intensity	n=1,755±509; 74% female; 83.6% non-Hispanic white; mean age, 47.6 years; mean baseline BMI, 33.6 kg/m²	All participants were given weight loss medications during year 1 (4% reported use). RCT1: bookHEALTH manual and eHEALTH tools (basic Internet component) RCT2: same as RCT1 with interactive version of eHEALTH that provided tailored feedback RCT3: same as RCT2 with added telephonic coaching support every 2 weeks and personalized e-mail	Primary outcome: change in weight Secondary outcomes: change in blood pressure and physical activity	Weight: Participants in all groups lost a mean of 4.6% at 6 months, 4.6% at 12 months, and 3.7% at 15–18 months (no differences between groups). Blood pressure: In all groups, mean SBP decreased (129.8 mm Hg to 124.3 mm Hg at 12 months; p<0.01). Exercise: The proportion of all participants engaging in regular physical activity increased 29.1% to 40.2% at 12 months and to 44.2% at 15–18 months.	6
Hunter et al.²² (2008): 6-month weight loss and weight gain prevention study comparing an Internet treatment with UC	n=451→446; U.S. Air force males and females; 50% female; mean age, 34 years; mean BMI, 29.0 kg/m²	UC: one visit annually with primary care provider; access to workout facilities, cooking classes, nutrition consultations, expectation of three workouts per week (U.S. Air Force requirement) BIT: UC plus electronic food and exercise records, weekly counselor feedback, weight loss and calorie goals, weekly lessons, Web site information, two motivational interviewing calls	Primary outcome: weight at 6 months Secondary outcomes: BMI, waist circumference, body fat percentage, 5% or more weight loss, diet intake, and physical activity	Weight: BIT versus UC, −1.3±4.1 kg versus 0.6±3.4 kg (p<0.001) BMI: BIT versus UC, −0.5 versus +0.5 kg/m² (p<0.001) Waist circumference: BIT versus UC, −2.1 versus −0.4 cm (p<0.001) Body fat percentage: BIT versus UC, −0.4% versus +0.6% (p<0.001) 5% weight loss: BIT versus UC, 22.6% versus 6.8% (p<0.001). Diet: significant group×time interaction for fruit and vegetable intake (p=0.002) and meat and snack intake (p=0.045) Physical activity: no difference between groups	6
Kraschnewski et al.²³ (2011): 12-week weight loss study comparing a Web-based intervention with control	n=100±88; 69.7% female; 90.8% white; mean age, 50.3 years; mean BMI, 33.2 kg/m²	Web site (ActiveTogether) guided to implement 36 weight control behaviors, entered weight weekly, Web site access, videos of role models, tailored feedback at log-in, e-mail reminders; n=50±43 Control: wait-list control; n=50±45	Primary outcome: change in weight Secondary outcomes: blood pressure, caloric intake, quality of life, use of weight control practices	Weight: Web site versus control, 1.4 kg versus 0.6 kg (p<0.01) Blood pressure: Web site versus control SBP, −7.1 mm Hg versus −3.6 mm Hg (not significant); diastolic, −1.5 mm Hg versus 2.2 mm Hg (p<0.05) Quality of life: Web site versus control, 2.6 versus 0.6 (not significant) Weight control: Web site versus control, 0.4 versus 0.0 (p<0.05) Diet intake: Web site versus control, −174.9 kcal versus −139.8 kcal (not significant)	8
McConnon et al.²⁴ (2007): 12-month study comparing a group receiving an Internet program for obesity management and a UC group	n=221±131; 77% female; 95% white; mean age, 45.8 years; mean BMI, 34.4 kg/m² Internet group: n=111±54 UC group: n= 110±77	Internet group: provided with access to a Web site with tool, advice, and information to support behavior change in terms of diet and physical activity patterns; individualized motivational feedback to participants and reminder e-mails for not visiting the Web site UC group: advised to follow same plan and given brief information	Primary outcome: change in weight Secondary outcomes: physical activity level, lifestyle and dietary habits, quality of life	Weight loss: The UC group lost 1.9 kg versus 1.3 kg in the Internet group (p=0.56) at 12 months. No significant changes in secondary outcomes between the two groups at 6 or 12 months.	5
Micco et al.²⁵ (2007): 12-month RCT to compare weight loss outcomes on an Internet-only weight loss program with the same program supplemented by monthly in-person visits	n=123→77 Internet only: n=62→39; 23% male; mean age, 46.5 years; mean BMI, 32.3 kg/m² Internet+in-person: n=61→38; 12% male; mean age, 47.1 years; mean BMI, 31.0 kg/m²	Internet: Participants were divided into groups and met weekly on an online chat room, provided lessons that focused on behavior modification, prescribed a maximum caloric intake, encouraged to exercise 5–7 days/week, had weekly homework and also submitted weekly electronic food journals, and got positive reinforcement. Internet+in-person treatment: Participants were given the same intervention as above with the addition of an in-person meeting that took the place of a monthly online chat session.	Primary outcome: weight loss at 6 and 12 months	There were no significant differences in weight loss between completers at 6 and 12 months. 6-month weight loss: Internet only, −9.2±7.0 kg; Internet+in-person, −6.9±4.2 kg (p=0.08) 12-month weight loss: Internet only, −8.1±7.5 kg; Internet+in-person, -–5.6±5.5 kg (p=0.10)	9
Morgan et al.²⁶ (2011): 12-month weight loss study comparing a comprehensive Internet program (SHED-IT) with an information-only control group	n=65 Internet: mean age, 37.5 years; mean weight, 99.1 kg Control group: mean age, 34.0 years; mean weight, 99.2 kg	Internet group: a 75-min information and Web site training session, information booklet, access to a comprehensive Web site, and 3 months of online support Information only: received a 60-min information session identical to the Internet group and received a weight loss booklet	Primary outcome: change in body weight and BMI Secondary outcomes: blood pressure, waist circumference	Change in weight: Both groups maintained significant weight loss at 12 months (p<0.001). No difference between groups (p=0.408) BMI: significant decrease in BMI in both groups (p<0.001). No difference between groups. Blood pressure and waist circumference: reduction in both groups at 12 months (p<0.001). Significant difference in SBP between Internet (−11 mm Hg) and control (−6 mm Hg) (p=0.03)	9
Morgan et al.²⁷ (2011): 3-month weight loss program to determine the effectiveness of a workplace program versus a control condition	n=110±86; 100% male; mean age, 44.4 years; mean BMI, 30.5 kg/m²	Workplace program: study Web site, information session, handbook, Web site tutorial and user guide, seven individualized dietary feedback sheets, group-based financial incentives, pedometer Control: 14-week wait-listed	Primary outcome: weight at 14 weeks Secondary outcomes: waist circumference, blood pressure, resting heart rate, physical activity, dietary habits	Weight loss: mean difference of 4.3 kg between groups (p<0.001). Significantly more participants in the workplace group lost 5% or greater of body weight (p<0.001). Significant treatment effects found for BMI, resting heart rate, waist circumference, SBP, and physical activity	6
Mouttapa et al.²⁸ (2011): 5-week weight loss intervention comparing a PNP with a control group	n=307→261; 100% female; 100% university staff; 59.1% white	Internet (PNP): Web site with nutrition information, goal-setting features, body assessments, individualized feedback Control: received no program	Primary outcome: weight loss Secondary outcomes: dietary intake frequencies, opinions on program	Weight loss: no significant intervention effect between pre-test and post-test. Intervention lost on average 1.3 lbs, whereas control lost 0.63 lbs. Dietary intake: no significant findings for vegetable and fruit intake. Significant increase in dairy intake for the PNP group compared with control (F=4.50, p<0.05) Opinions on program: Follow-up e-mails from the program averaged a score of 3.68/5. Program materials influencing weight loss behaviors scored a 3.04/5.	5
Paineau et al.²⁹ (2008): 8-month family-based intervention to improve diet quality and reduce weight, comparison of three groups	n=1,013 families→859 families Group A: 48.1% male children; 18.5% male adults; mean age of children, 7.7 years; mean age of adults, 40.4 years Group B: 50% male children; 16.1% male adults; mean age of children, 7.8 years; mean age of adults, 40.3 years Group C: 45.2% male children; 18.9% male adults; mean age of children, 7.6 years; mean age of adults, 40.6 years	Group A: advised to reduce fat and increase complex carbohydrates, monthly phone counseling and Internet-based monitoring Group B: advised to reduce fat and sugar intake and to increase complex carbohydrate intake, plus monthly phone counseling and Internet-based monitoring Group C: control, no intervention	Primary outcome: change in nutritional intake and BMI Secondary outcome: change in fat mass, physical activity, blood indicators, and quality of life	BMI: no significant changes in children. For parents, significant difference between Group B and control (p=0.01) Dietary intake: decrease in energy intake for both Group A and B compared with control (children, p<0.001; adults, p=0.02) No significant differences among groups for anthropometric changes in children (all increased) Fat mass: significant decrease in Group B for adults Blood indicators: no significant differences Physical activity: no significant differences in changes in adults or children between groups	6
Patrick et al.³⁰ (2011): 12-month weight loss program for men comparing a tailored Web site and modules with a control group	n=441; 100% male; 71% white; mean age, 43.9 years; two-thirds college graduates	Intervention: Web site with weekly modules, goal setting, and individualized feedback; focus on increasing fiber and fruits/vegetables, decreasing saturated fat intake, increasing steps per day and strength training Control: wait-list, given access to a Web site with information for men (hair loss, stress, injury prevention); at 12 months, crossed over to weight loss intervention	Primary outcome: weight loss Secondary outcomes: waist circumference, percentage energy from saturated fat, grams of fibers, fruit/vegetable intake, walk minutes per day	Weight loss: no significant differences between groups, but those who participated most in the intervention group had lower weights at 12 months compared with those who participated less. Waist circumference: no significant differences Percentage energy from saturated fat, grams of fiber and fruit/vegetable intake: significant increase (decrease in saturated fat) in intervention compared with control (p<0.001) Minutes walked per day: significant increase (16 min) in intervention compared with control (p<0.05)	6
Rothert et al.³¹ (2006): 6-month study comparing the use of a Web site with information only with a tailored behavioral management Web program (TES)	n=2,862±585 TES: 82.9% female; 35.4% African American; mean age, 45.6 years; mean BMI, 33.3 kg/m² Information only: 82.7% female; 35.8% African American; mean age, 45.2 years; mean BMI, 31.1 kg/m²	TES: individually tailored weight loss plan, opportunity to enroll a “buddy,” tailored action plans delivered at 1, 3, and 6 weeks, follow-up materials Information only: standard Kaiser Permanente Web site for weight loss and weight management	Primary outcome: % weight loss	Weight loss: those in the tailored Web group lost significant more weight versus information only (–3±0.3% versus −1.2±0.4%; p<0.0004)	6
van Weir et al.³² (2009): 6-month intervention comparing information plus phone counseling, Web site plus e-mail counseling, and UC on weight loss in a population of overweight working adults	n=1,386→982; 67% male; mean age, 43 years; mean BMI, 29.6 kg/m²; 34% obese; 14.9% smokers	All groups received the same printed weight loss materials. Phone: phone counseling every 2 weeks, program in a binder (10 modules on diet and physical activity), received a pedometer Internet: received program on a Web site, individualized modules, counseling by e-mail, reminders by text messaging UC: materials and no counseling	Primary outcome: weight loss Secondary outcome: fat, fruit and vegetable intake, physical activity, and waist circumference	Weight loss: significant weight loss in phone (95% CI, −2.2, −0.8; p<0.001) and Internet (95% CI, −1.3, −0.01; p=0.045) groups compared with control Dietary intake: significant decrease in fat intake (95% CI, −1.7, −0.2; p=0.01) in phone group compared with UC Physical activity: increase by 866 METs minutes/week for phone group compared with control (95% CI, 203, 1,530; p=0.01) Waist circumference: significant decrease in Internet intervention (95% CI, −2.1, −0.4; p=0.01) compared with UC No changes in fruit/vegetable intake	6
Webber et al.³³ (2008): 16-week study comparing a Web site Internet versus an enhanced Web site intervention for overweight and obese women	n=66±65; 100% female; 86% white; average age, 55 years; average BMI, 31.1 kg/m²	Web site: study Web site and weekly lessons, message boards, self-monitoring, Web links Enhanced Web site: study Web site and weekly lessons, message boards, self-monitoring, Web links, weekly online chat room sessions led to using motivational techniques	Primary outcome: change in weight and 5% weight loss Secondary outcome: change in lifestyle behaviors (calories consumed and calories burned)	Weight change: Both groups lost significant weight (p<0.001). No group×time interaction (p=0.19). 67% of the minimal group and 46% of the enhanced group lost at least 5% of their baseline weight. Lifestyle changes: Both groups had a significant decrease in calorie consumption (p<0.01) and fat intake; no differences between groups. Both groups had a significant increase in calories burned per week (p<0.01); no difference between groups.	5
Tate et al.³⁴ (2003): 12-month RCT comparing the effectiveness of basic Internet with Internet and electronic behavioral counseling on individuals at risk for type 2 diabetes	n=92→77 Control: n=46→39; 11% male; 89% white; mean age, 47.3 years; mean weight, 89.4 kg; mean BMI, 33.7 kg/m² Intervention: n=46→38; 9% male; 89% white; mean age, 49.8 years; mean weight, 86.2 kg; mean BMI, 32.5 kg/m²	Control: Participants were seen at baseline and 3, 6, and 12 months for measurements. All attended a 1-h introductory Internet instruction and behavioral counseling session. Control: Access to a study Web site that included a tutorial on weight loss, weight loss resources, a message board, and weekly e-mails for weight loss information and reminders to submit weight as Intervention: In addition to the methods above, participants communicated with a behavioral counselor, submitted diaries of caloric intake and exercise; counselors e-mailed feedback, reinforcement, recommendations, and answers to questions.	Primary outcome: change in weight Secondary outcome: change in waist circumference	Weight loss: significant difference between control (−2.0±5.7 kg) and intervention (−4.4±6.2 kg) (p=0.04) Waist circumference: significant difference between control (−4.4±5.7 cm) and intervention (−7.2±7.5 cm) (p=0.05)	7
Tate et al.³⁵ (2006): 6-month RCT comparing effectiveness of HC and computer AF to improve self-directed weight loss	n=192→155 Control: n=67→59; 18% male; 9% minority; mean age, 49.9 years; mean weight, 88.3 kg; mean BMI, 32.3 kg/m² Computer AF: n=61→44; 13% male; 10% minority; mean age, 49.7 years; mean weight, 89.0 kg; mean BMI, 32.7 kg/m² HC: n=64→52; 16% male; 13% minority; mean age, 47.9 years; mean weight, 89.0 kg; mean BMI, 32.8 kg/m²	All groups: All participants were recommended a calorie-restricted diet of 1,200–1,500 kcal/day plus the use of liquid weight loss beverages (Slim-Fast), encouraged to increase physical activity to expend 1,050 kcal/week, and instructed on how to use the Slim-Fast Web site. AF and HC: These groups had additional access to an electronic food and exercise monitoring diary and message boards with other participants in the group. The AF group received a preprogrammed computer e-mail based on diary submissions. The HC group received weekly e-mails from a human weight loss counselor whom they had not met in-person.	Primary outcome: change in body weight	Weight loss at 6 months: control, −2.6±5.7 kg; AF, −4.9±5.9 kg; HC, −7.3±6.2 kg. Weight loss was significantly different between control and HC group (p<0.001). The AF group did not differ significantly from the control (p=0.16) or the HC group (p=0.15).	7
Text messaging or e-mail
Haapala et al.³⁶ (2009): 1-year RCT comparing weight loss using a text message intervention versus with a control group	n=125 Control: n=63→40; 24% male; mean age, 38.0 years; mean weight, 86.4 kg; mean BMI, 30.4 kg/m² Intervention: n=62→45; 21% male; mean age, 38.1 years; mean weight, 87.5 kg; mean BMI, 30.6 kg/m²	Control: received no intervention but was not discouraged from joining another weight loss program Intervention: received Weight Balance^® program, which calculates energy requirements and sends texts indicating weight goals, amount of food to be consumed daily, and days remaining to achieve weight loss goals. It advised dieters to reduce unnecessary foods high in sugar and fat, increase physical activity, and regular weight reporting.	Primary outcome: change in weight and waist circumference	Change in weight and waist circumference: no significant changes in control group. Significant weight loss in intervention: 4.5±5.0 kg (t=5.8, p<0.0001). Significant reduction in waist circumference in intervention: 6.3±5.3 cm	6
Patrick et al.³⁷ (2009): 4-month RCT to determine the effectiveness of SMS and MMS on weight loss or weight maintenance versus a control group	n=78→65 Intervention: n=39→26; 24% male; 18% Hispanic; 21% black; mean age, 47.4 years Control: n=39→26; 16% male; 31% Hispanic, 13% black; mean age, 42.4 years	Intervention: SMS and MMS about behavioral and dietary strategies sent to participants based on preferences. Users could choose the time and frequency of the messages. Topics, questions, and tips tailored to participants' eating behaviors were sent via messaging. Received nutrition topics and strategies, a food and exercise journal, and 5–15-min monthly phone calls from a health counselor to encourage participation in the program Control: Participants were mailed two pages of printed material on weight loss and nutrition monthly.	Primary outcome: weight change	Weight change: Intervention lost significantly more weight than control (–1.99 kg compared with control; p=0.04).	6
Shapiro et al.³⁸ (2012): 12-month RCT to compare the effectiveness of receiving daily interactive text messages with a monthly electronic newsletter	n=170→143→130 Intervention: n=81→64→57; 33% male; 68% white; mean age, 43.1 years Control: n=81→79→73; 36% male; 62% white; mean age, 40.9 years	Intervention: received SMS and MMS four times/day, including tips, facts, and questions requiring a reply. Participants were asked to report step count daily (pedometer provided) and weights weekly and received personalized feedback. Received weekly message regarding weight change and a monthly electronic newsletter with diet and physical activity information Control: received the same monthly electronic newsletters	Primary outcome: weight loss at 6 months	Weight loss: no significant difference in weight loss at 6 months between groups (control, 1.53±7.66 lbs; intervention, 3.72±9.37 lbs)	8
Thomas et al.³⁹ (2010): Patients who lost ≥5% of initial body weight participated in a 6-month RCT determining the efficacy of e-mail support for weight maintenance.	n=55→49 Intervention: n=28→26; mean age, 43.2 years; median body weight loss achieved (%) before entry into the study (IQR) (range), 11 (8) (6–20) Control: n=27→23; mean age: 46.2 years; median body weight loss achieved (%) before entry into the study (IQR) (range), 9.5 (7) (5–22)	Intervention: received a weekly e-mail from a dietician with behavioral and exercise advice. Participants sent an e-mail including current weight monthly to the dietician. Control: no intervention	Primary outcome: body weight maintained at the end of 6 months	Weight loss initial versus weight loss maintained: 11.2–7.8 kg (p=0.003) for control group and 12.4–10.9 kg (p=0.278) for intervention group, suggesting e-mail was successful in reducing amount of weight regain	7
Smartphone applications/mobile devices
Burke et al.⁴⁰ (2010): 24-month RCT comparing self-monitoring techniques on weight loss and dietary intake using PDA	n=210→192 PDA: n=68→64; 14.7% male; 80.9% white; mean age, 46.7 years; mean BMI, 34.9 kg/m² PDA+feedback, n=70→65; 15.7% male; 78.6% white; mean age, 46.4 years; mean BMI, 34.8 kg/m² Paper record: n=72→63; 15.3% male; 76.4% white; mean age, 47 years; mean BMI, 34.8 kg/m²	All groups received the same standard behavioral intervention including daily self-monitoring of eating and exercise, group sessions, daily dietary goals, and weekly exercise goals. PDA: used a PDA with software to track exercise and energy and fat consumption PDA+feedback: used PDA with a custom software program to provide daily feedback messages providing positive reinforcement and guidance based on entries Paper record: Used standard paper diaries and were instructed to record caloric intake, fat gram content, and minutes of exercise	Primary outcome: weight loss at 6 months	Percentage weight loss was statistically significant (p<0.01) for all treatment groups. Percentage (mean±SD): PDA, 5.5±7.0%; PDA+feedback, 7.3±6.6%; paper record, 5.3±5.9%	6
McDoniel et al.⁴¹ (2009): 12-week RCT comparing a standard nutritional program with computer self-monitoring	n=111→80 Control: n=56→41; 37.5% male; 76.8% white; mean age, 44.9 years, mean BMI, 36.2 kg/m²; Internet and e-mail use (days/week), 6.0±1.6 Intervention: n=55→39; 38.2% male; 80.0% white; mean age, 45.9 years; mean BMI, 37.9 kg/m²; Internet and e-mail use (days/week), 5.7±1.7	Control: received a standard nutritional 3-day meal plan, 30-day paper journal for self-monitoring nutrition, activity, and body weight, and individual counseling by an exercise physiologist at 4 and 12 weeks. Intervention: received a nutritional program generated by MedGem© Analyzer based on individuals' measured resting metabolic rate, computerized self-monitoring software program (BalanceLog©), and individual counseling by an exercise physiologist at 4 and 12 weeks	Primary outcome: body weight Secondary outcomes: arterial blood pressure, the Weight Efficacy Lifestyle questionnaire for assessing weight attitude, perceived behavioral control, and weight self-efficacy	Body weight: There was no significant difference in body weight between groups over time (F_1,110=1.77, p=0.19). Absolute change in body weight was significant for each group (control, −3.7±4.2 kg; intervention, −3.5±4.2 kg). Blood pressure: No difference in blood pressures between groups. Groups experienced a significant reduction in SBP (–4.0±11.8 mm Hg; p=0.02) Weight attitude, perceived behavioral control, and weight self-efficacy: showed significant improvement between baseline and 12 months in each group
Pellegrini et al.⁴² (2012): 6-month RCT comparing a technology-based system, an in-person behavioral weight loss intervention, and a combination of both	n=51→39 SBWL: n=17→9; 0% male; 17.6% African American; mean age, 45.1 years; mean weight, 88.6 kg; mean BMI, 33.1 kg/m² SBWL+technology: n=17→17; 23.5% male; 5.9% African American; mean age, 43.3 years; mean weight, 102.1 kg; mean BMI, 34.7 kg/m² Technology: n=17→13; 17.6% male; 5.9% African American; mean age, 44.1 years; mean weight, 92.3 kg; mean BMI, 33.4 kg/m²	SBWL: Weekly meetings that encouraged behavioral modification, calorie restriction, increase in physical activity, and self-monitoring in paper diaries. Interventionists provided written feedback weekly. SBWL+technology: received the same meetings in addition to diet and exercise goals as SBWL. Received a BodyMedia (Pittsburgh, PA) Fit, an armband that tracked energy expenditure during waking hours. Interventionists provided written feedback weekly. Technology: Behavioral lessons were mailed each week. Participants received the same behavioral goals for diet and exercise and a monthly telephone call from a counselor.	Primary outcome: Body weight Secondary outcome: physical activity	Weight loss: significant for all groups but no significant difference among groups (SBWL, −7.1±6.2 kg; SBWL+technology, −8.8±5.0 kg; technology, −7.6±6.6 kg; p<0.001) Physical activity: significant increases reported in all groups but no significant difference among groups (SBWL, 473.9±800.7 kcal/week; SBWL+technology, 713.9±1,278.8 kcal.week; technology, 1,066.2±1,371 kcal/week)	4
Polzien et al.⁴³ (2007): 12-week RCT to compare SBWP with INT-TECH and CON-TECH	n=57→50 SBWP: n=19→16; 36.8% minority representation; mean age, 40.2 years; mean body weight, 89.1 kg; mean BMI, 33.6 kg/m² INT-TECH: n=19→16; 36.8% minority representation; mean age, 41.1 years; mean body weight, 91.0 kg; mean BMI, 33.4 kg/m² CON-TECH: n=19→18; 42.1% minority representation; mean age, 46.0 years; mean body weight, 86.6 kg; mean BMI, 32.6 kg/m²	SBWP: received seven in-person counseling sessions focused on diet and exercise behaviors; instructed to reduce caloric intake to 1,200–1,500 kcal/day, dietary fat ≤20% of total energy intake, and exercise to progress from 20 to 40 min/day 5 days/week CON-TECH: received all components of the SBWP with a wearable body monitor (Sensewear Pro armband; BodyMedia) for energy expenditure measurement. INT-TECH: received all components of SBWP, only used the armband during Weeks 1, 5, and 9, and were restricted to a paper diary during the “non-technology” weeks	Primary outcome: weight loss Secondary outcomes: leisure-time physical activity and dietary intake	Weight loss: SBWP, −4.1±2.8 kg; INT-TECH, 3.4±3.4 kg; CON-TECH, 6.2±4.0 kg. Significant weight loss was observed in all groups with no significant differences among groups. Leisure-time physical activity: significantly increased for all groups (p<0.01) Dietary intake: significantly decreased in all groups (p<0.01) with no significant differences among groups	6
Shuger et al.⁴⁴ (2011): 9-month RCT comparing the efficacy of a caloric expenditure monitor with self-directed diet and group-based program on weight loss and waist circumference	n=197→123 Standard care: n=50→26; 16% male; 60% white; mean age, 47.2 years GWL: n= 49→28; 20.4% male; 68.8% white; mean age, 46.8 years GWL+SWA: n=49→37; 18.4% male; 71.4% white; mean age, 45.7 years SWA: n= 49→32; 18.4% male; 67.4% white; mean age, 47.7 years	Standard care: received a self-directed weight loss manual; asked to self-monitor intake and physical activity GWL: received 14 sessions over the first 4 months with weekly weigh-ins. During the final 5 months, participants received six personal phone-counseling sessions. SWA: received an armband, wristwatch, and Weight Management Solutions Web account. Participants received real-time feedback on energy expenditure and minutes spent in moderate and vigorous exercise. GWL+SWA: received all components of the GWL and SWA interventions	Primary outcome: change in body weight Secondary outcome: waist circumference	Weight reduction: There were significant reductions in weight for the GWL (1.86 kg), SWA (3.55 kg), and GWL+SWA (6.59 kg) groups (p≤0.05). GWL+SWA showed a significant weight reduction compared with the standard care group (p=0.04). Waist circumference: There was a significant reduction in waist circumference in all four groups (standard care, 3.49 cm [p<0.0004]; GWL, 2.42 cm [p<0.008]; SWA, 3.59 cm [p<0.001]; and GWL+SWA, 6.77 cm [p<0.001]).	6
Spring et al.⁴⁵ (2013): 12-month RCT measuring weight loss through self-monitoring and coaching calls to supplement standard treatment	n=70→69 Control: n=35; 43.4% male; 8.6% Hispanic, 22.9% black; mean age, 57.7 years; mean weight, 110.1 kg; mean BMI, 35.8 kg/m² Intervention: n=35→34; 42% male; 2.9% Hispanic, 26.5% black; mean age, 57.7 years; mean weight, 113.7 kg; mean BMI, 36.9±5.4 kg/m²	Control: attendance at biweekly MOVE! sessions led by dieticians, psychologists, or physicians Intervention: attendance of the biweekly MOVE! Sessions. Self-monitoring caloric intake using a PDA every day for the first 2 weeks, then weekly until the end of 6 months, with biweekly individualized guidance based on uploaded data. During the weight maintenance phase (months 7–9) participants recorded data biweekly and then 1 week of data per month (months 10–12), with phone call feedback only provided if no data were submitted.	Primary outcome: weight loss at 6 months and 12 months	Weight loss at 6 months: control, 1.0 kg (95% CI, −0.7, 2.5); intervention, 4.5 kg (95% CI, 2.1, 6.8) Weight loss at 12 months: control, −0.02 kg (95% CI, −2.1, 2.1); intervention, 2.9 kg (95% CI, 0.5, 6.2)	7
Turner et al.⁴⁶ (2011): 6-month RCT comparing weight loss between podcast group and a podcast+mobile self-monitoring group	n=96→86 Control: n=49→44; 27% male; 78% white; mean age, 43.2 years; mean BMI, 32.2 kg/m² Intervention: n=47→42; 23% male; 75% white; mean age, 42.6 years; mean BMI, 32.9 kg/m²	Both groups received two podcasts per week for 3 months and two minipodcasts per week for 3–6 months; the content was designed using social cognitive theory constructs containing information on nutritional and physical activity, blogs, soap opera, and goal-setting activities. Control: received a book with calorie and fat gram amounts to assist with dietary intake Intervention: instructed to download a diet and physical activity monitoring application (FatSecret's Calorie Counter application) and Twitter. Participants logged onto Twitter at least once daily to read messages from the study coordinator and were encouraged to post daily.	Primary outcome: change in body weight	Weight loss did not significantly differ by group at 6 months: control, –2.7±5.6%; intervention, −2.7±5.1%	7
Chat room
Gow et al.⁴⁷ (2010): 6-week RCT to demonstrate the feasibility of an online intervention to prevent weight gain among college students	n=159; 26% male; 22.2% African American, 10.8% Asian	Asked to report weekly weights and received a graph with individualized change in weight. Internet intervention: 45-min weekly sessions delivered via Blackboard© that focused on environmental, personal, and behavioral factors involved in healthy weight maintenance along with participatory activities Combined feedback and Internet intervention: Participants received the 6-week online intervention as well as weight and caloric feedback.	Primary outcome: change in BMI	The combined intervention group had significantly lower BMI scores than the control group (mean, 24.13; SE, 0.09; p<0.05). The Internet intervention group and feedback group did not significantly differ on BMI compared with the control group (p>0.05).	6
Harvey-Berino et al.⁴⁸ (2010): 6-month RCT to evaluate the efficacy of an Internet weight loss program and to determine if adding in-person sessions improves outcomes	n=481→462 Internet: n=161→159; 8% male; 30% African American; mean age, 46.2 years; mean BMI, 35.6 kg/m² In-person: n=158→150; 6% male; 29% African American; mean age, 46.7 years; mean BMI, 36.0 kg/m² Hybrid: n=162→153; 6% male; 26% African American; mean age, 46.7 years; mean BMI, 35.6 kg/m²	All conditions received the 6-month behavioral weight loss program, which focused on modification of eating and exercise. In-person: Subjects in groups of 15–20; weekly sessions, a paper journal to monitor exercise and eating, and a calorie and fat counting book Internet: Participants met weekly in chat groups of 15–20 subjects and received materials for the session, access to an online database to monitor caloric intake in an online journal, and educational online resources. Hybrid: same resources as the Internet group but substituted one weekly online chat with an in-person meeting	Primary outcome: weight loss and percentage of subjects achieving a 5% and 7% weight loss	Weight loss: in-person, −8.0±6.1 kg; Internet, −5.5±5.6 kg; hybrid, −6.0±5.5 kg (significant difference among conditions, p<0.01) Percentage of participants achieving 5% weight loss: no significant difference among groups (p=0.12) Percentage of participants achieving 7% weight loss: in-person, 56.0%; Internet, 37.7%; hybrid, 44.4% (significantly different)	6
Wing et al.⁴⁹ (2006): 18-month RCT comparing Internet, face-to-face, and control interventions on weight maintenance	n=314→291 participants who lost a mean of 19.3 kg over the previous 2 years were randomized to one of the three groups. Control: n=105→98; 17.1% male; mean age, 52.0 years; mean weight, 78.8 kg; mean BMI, 29.1 kg/m²; weight loss from highest weight in prior 2 years, 18.6±10.3 kg (17.9±7.0%) Internet: n=104→101; 19.2% male; mean age, 50.9 years; mean weight, 76.0 kg; mean BMI, 28.1 kg/m²; weight loss from highest weight in prior 2 years, 19.2±11.1 kg (18.3±7.7%) Face-to-face: n=105→92; 20.0% male; mean age, 51.0 years; mean weight, 78.6 kg; mean BMI, 28.7 kg/m²; weight loss from highest weight in prior 2 years, 20.0±11.6 kg (19.1±8.0%)	Control: Participants received a quarterly newsletter with information about diet, exercise, and weight control. Face-to-face: attended weekly meetings for the first month and then monthly meetings. This included weigh-ins and group sessions. Participants were asked to weigh themselves weekly and report weight through an automated telephone system. Internet: Attended meetings with the same frequency as the face-to-face group but met online in a chat room, reviewing same content provided in the face-to-face group. They also had access to a message board and Web site that included treatment lessons	Primary outcome: weight gain over a period of 18 months	Weight gain: face-to-face, 2.5±6.7 kg; Internet, 4.7±8.6 kg; control, 4.9±6.5 kg. There was a significant difference in weight gain between face-to-face and control groups (absolute difference, 2.4 kg; 95% CI, 0.002, 10.8; p=0.05)	6

AF, automated feedback; BIT, behavioral Internet therapy; BMI, body mass index; CI, confidence interval; CON-TECH, continuous technology-based program; GWL, Group Weight Loss; HC, human e-mail counseling; INT-TECH, intermittent technology-based program; IQR, interquartile range; METs, metabolic equivalents to task; MMS, multimedia message service; PDA, personal digital assistant; PE, physical education; PNP, personalized nutrition planner; RCT, randomized controlled trial; RD, registered dietician; SBP, systolic blood pressure; SBWL, standard behavioral weight loss; SBWP, standard in-person behavioral weight control program; SD, standard deviation; SE, standard error; SMS, short message service; SWA, SenseWear armband; UC, usual care.