FIG. 5.
Fusion and reverse transcription of the targeting nanovirus. (A) 1×105 Hela cells were treated or not treated with vacuolar-type H+-ATPase inhibitor bafilomycin-A for 30 min then transduced with VSV-G or cRGD-nVSV-G (p24=10 ng) with or without bafilomycin-A for 4 hr. (B) Transduction by the nanovirus is inhibited by reverse transcriptase AZT. 1×105 Hela cells were treated or not treated with AZT for 30 min then transduced with VSV-G or cRGD-nVSV-G (p24=10 ng) for 4 hr with or without AZT. Color images available online at www.liebertpub.com/hgtb