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. 2015 Feb 5;370(1661):20140162. doi: 10.1098/rstb.2014.0162

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© 2014 The Author(s) Published by the Royal Society. All rights reserved.

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Figure 4. — Summary of how differences in cell shape and polarity as well as the spreading dynamics are controlled by filopodia-nanowire (NW) interactions. The first row describes for flat glass (2D) how fibroblasts undergo a rapid phase transition from filopodia-rich initial state towards a lamellipodia-mediated spreading. The second row shows how cells sitting at interfaces between flat surface and NWs contact the NWs, quickly adhere, align and spread towards NW adhesions, while filopodia peel off from the adjacent flat surfaces. After approximately 30 min, delayed lamellae/ruffle formation leads to migration towards the flat surface (data not shown). This dynamic change in topography preference is reversible during mitotic rounding of fibroblasts. The bottom row shows how fibroblasts on purely NW-decorated surfaces quickly spread via aligned filopodia-NW adhesions into dendritic shapes, without formation of lamellipodia. Adapted from Albuschies & Vogel [17]. (Online version in colour.)