Figure 5.

Cellular uptake of nanoparticulate ligand-modified (LM) Fe(III) poly oxo-hydroxide by Caco-2 cells. Transmission electron microscopy images showing differentiated Caco-2 cells incubated with LM Fe(III) poly oxo-hydroxide. (a) Arrows show particle clusters adhering to the cell membrane microvilli (scale bar, 500 nm). (b) Arrows indicate invagination on the cell membrane (scale bar, 100 nm). (c,d) Arrows indicate Fe accumulation inside the cell (scale bars: panel c, 500 nm and panel d, 100 nm). Reproduced with permission from Pereira et al. [25].