Table 2.
White matter clusters with reduced fractional anisotropy (FA) in pediatric OCD patients versus healthy controls
| Cluster label and anatomical localization | Voxels | MNI coordinates | FA | ||||
|---|---|---|---|---|---|---|---|
| x | y | z | OCD | HC | p | ||
| 1. Bilateral frontal (ATR, UF, IFOF, forceps minor, anterior corona radiata) and corpus callosum (genu, body, splenium) | 9,022 | 20 | 37 | 6 | 0.533 ± 0.191 | 0.573 ± 0.188 | 0.026 |
| 2. Right cingulate and basal ganglia: anterior cingulate cortex (UF), anterior limb of IC (ATR), putamen (UF), amygdala (ILF), cerebral peduncle (CST), thalamus, and posterior limb of IC (ATR) | 1,454 | 23 | 0 | −9 | 0.419 ± 0.157 | 0.460 ± 0.158 | 0.035 |
| 3. Right posterior cerebral cortex: lateral occipital and angular gyri (SLF) | 132 | 36 | −56 | 33 | 0.423 ± 0.100 | 0.500 ± 0.098 | 0.048 |
| 4. Right inferior frontal lobe (subcallosal cortex) | 50 | 8 | 21 | −19 | 0.296 ± 0.067 | 0.370 ± 0.107 | 0.049 |
| 5. Right inferior frontal: orbitofrontal cortex | 36 | 8 | 37 | −22 | 0.267 ± 0.067 | 0.323 ± 0.073 | 0.050 |
| 6. Right thalamus | 14 | 18 | −5 | 11 | 0.639 ± 0.041 | 0.668 ± 0.038 | 0.050 |
| 7. Right caudate, anterior IC (ATR) | 6 | 22 | −4 | 24 | 0.430 ± 0.056 | 0.493 ± 0.081 | 0.050 |
ATR anterior thalamic radiation, CST corticospinal tract, IC internal capsule, IFOF inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus, UF uncinate fasciculus.