Table 2.
Predicted difference in cardiovascular traits relative to zero alcohol consumption at several levels of alcohol consumption and predicted curve features in the Alcohol-ADH1B Consortium. Only calculated for traits with evidence of non-linearity
| Outcome | Difference in outcome (95% CIa) |
Level of alcohol consumption at nadir (units/week) (95% CIa) | Difference in outcome at optimal alcohol consumption (95% CIa) | Level of alcohol consumption with outcome equal to that at zero (units/week) (95% CIa) | |||
|---|---|---|---|---|---|---|---|
| 3.04 units/weekc | 12.15 units/weekc | 31.90 units/weekc | 84.52 units/weekc | ||||
| SBP (mmHg) | 0.1 (−5.5, 6.1) | 5.2 (−2.6, 13.9) | 12.4 (3.4, 22.1) | 22.8 (12.2, 34.6) | 1.0 (0.0, 3.6) | −0.7 (−5.4, 0.0) | 2.8 (0.0, 19.6) |
| Non-HDL-C (mmol/l) | −0.39 (−0.79, 0.06) | −0.15 (−0.72, 0.47) | 0.40 (−0.28, 1.10) | 1.30 (0.45, 2.16) | 3.2 (0.7, 6.0) | −0.39 (−0.85, −0.03) | 16.9 (2.1, 48.2) |
| BMI (kg/m2) | −0.6 (−2.2, 0.8) | 0.2 (−2.0, 2.1) | 1.6 (−0.8, 3.8) | 3.9 (1.2, 6.3) | 2.3 (0.0, 6.0) | −0.6 (−2.3, 0.0) | 10.1 (0.0, 48.4) |
| WC (cm) | −0.6 (−4.7, 3.5) | 1.9 (−3.9, 7.8) | 5.7 (−0.6, 12.5) | 11.5 (4.5, 19.2) | 1.5 (0.0, 5.4) | −0.8 (−4.9, 0.0) | 5.3 (0.0, 37.4) |
| CRPb (mg/l) | −0.29 (−0.68, 0.15) | −0.15 (−0.68, 0.50) | 0.22 (−0.37, 0.95) | 0.83 (0.15, 1.69) | 3.5 (0.0, 7.2) | −0.30 (−0.75, 0.00) | 19.4 (0.0, 66.0) |
SBP, systolic blood pressure; Non-HDL-C, non high-density lipoprotein cholesterol; BMI, body mass index; WC, waist circumference; CRP, C-reactive protein.
aDerived using 10 000 bootstrap samples.
bLog-transformed prior to analysis.
cWeekly units of alcohol values are medians of observed values in categories representing low (1–7 units/week), moderate (7–21 units/week), heavy (21–70 units/week) and very heavy (70+ units/week) alcohol consumption in the analysis of Holmes et al.13